Early Release Articles (date view)

May 5, 2025

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Machine Learning for Protein Science and Engineering Backbone Conditional Protein Sequence Design

Justas Dauparas

Cold Spring Harb Perspect Biol May 5, 2025;a041517 First published online May 5, 2025 doi:10.1101/cshperspect.a041517

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Machine Learning for Protein Science and Engineering Machine Learning for Protein Science and Engineering

Peter K. Koo,
Christian Dallago,
Ananthan Nambiar,
and Kevin K. Yang

Cold Spring Harb Perspect Biol May 5, 2025;a041877 First published online May 5, 2025 doi:10.1101/cshperspect.a041877

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Developmental Dynamics: Guided Morphogenesis and Self-Organization across Scales Epigenetics Beyond the Cell: Supracellular Organization of Fate and Form in Morphogenesis

Rubens Sautchuk, Jr.,
Sichen Yang,
Amy Shyer,
and Alan Rodrigues

Cold Spring Harb Perspect Biol May 5, 2025;a041497 First published online May 5, 2025 doi:10.1101/cshperspect.a041497

April 15, 2025

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Telomeres and Telomerase Structural Biology of Telomerase and Associated Factors

Zala Sekne,
Patryk Ludzia,
Sebastian Balch,
and Thi Hoang Duong Nguyen

Cold Spring Harb Perspect Biol April 15, 2025;a041697 First published online April 15, 2025 doi:10.1101/cshperspect.a041697

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Evolution and Development of Neural Circuits Bringing Chandelier Cells Out of the Shadows: Exploring the Development of a Unique Neuron Type in the Brain

Clara Lenherr,
Guilherme Neves,
Marcio Guiomar de Oliveira,
and Juan Burrone

Cold Spring Harb Perspect Biol April 15, 2025;a041506 First published online April 15, 2025 doi:10.1101/cshperspect.a041506

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Cell Migration Modeling and Simulating Single and Collective Cell Motility

Jupiter Algorta,
Ali Fele-Paranj,
Jack M. Hughes,
and Leah Edelstein-Keshet

Cold Spring Harb Perspect Biol April 15, 2025;a041796 First published online April 15, 2025 doi:10.1101/cshperspect.a041796

April 10, 2025

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Telomeres and Telomerase Therapeutic Opportunities for Alternative Lengthening of Telomeres (ALT) Cancers

Jixuan Gao and
Hilda A. Pickett

Cold Spring Harb Perspect Biol April 10, 2025;a041691 First published online April 10, 2025 doi:10.1101/cshperspect.a041691

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Telomeres and Telomerase Shedding Light on Telomere Replication, Insights from the Fission Yeast Schizosaccharomyces pombe

Stéphane Coulon

Cold Spring Harb Perspect Biol April 10, 2025;a041704 First published online April 10, 2025 doi:10.1101/cshperspect.a041704

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Telomeres and Telomerase Biogenesis and Regulation of Telomerase during Development and Cancer

Lu Chen and
Luis Francisco Zirnberger Batista

Cold Spring Harb Perspect Biol April 10, 2025;a041692 First published online April 10, 2025 doi:10.1101/cshperspect.a041692

March 17, 2025

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Telomeres and Telomerase Epigenetics of Human Telomeres

Nicole Bettin,
Mélina Vaurs,
and Anabelle Decottignies

Cold Spring Harb Perspect Biol March 17, 2025;a041706 First published online March 17, 2025 doi:10.1101/cshperspect.a041706

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Telomeres and Telomerase Telomeres and Human Disease

Sharon A. Savage

Cold Spring Harb Perspect Biol March 17, 2025;a041684 First published online March 17, 2025 doi:10.1101/cshperspect.a041684

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Telomeres and Telomerase Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions

Patricia L. Abreu,
Valentina Riva,
Luca Zardoni,
and Claus M. Azzalin

Cold Spring Harb Perspect Biol March 17, 2025;a041683 First published online March 17, 2025 doi:10.1101/cshperspect.a041683

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Telomeres and Telomerase In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function

Elia Zanella and
Ylli Doksani

Cold Spring Harb Perspect Biol March 17, 2025;a041694 First published online March 17, 2025 doi:10.1101/cshperspect.a041694

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Skeletal Muscle Biology Proteins of the Triadic Excitation–Contraction Coupling Complex in Skeletal Muscle

Ting Chang,
Rachel Sue Zhen Yee,
George G. Rodney,
and Susan L. Hamilton

Cold Spring Harb Perspect Biol March 17, 2025;a041482 First published online March 17, 2025 doi:10.1101/cshperspect.a041482

February 10, 2025

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Telomeres and Telomerase Oxidative Stress and DNA Damage at Telomeres

Patricia L. Opresko,
Samantha L. Sanford,
and Mariarosaria De Rosa

Cold Spring Harb Perspect Biol February 10, 2025;a041707 First published online February 10, 2025 doi:10.1101/cshperspect.a041707

December 18, 2024

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Telomeres and Telomerase Telomere Protection in Stem Cells

Marta Markiewicz-Potoczny and
Eros Lazzerini Denchi

Cold Spring Harb Perspect Biol December 18, 2024;a041686 First published online December 18, 2024 doi:10.1101/cshperspect.a041686

November 25, 2024

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Developmental Dynamics: Guided Morphogenesis and Self-Organization across Scales Four-Dimensional Bioprinting: Harnessing Active Mechanics to Build with Living Inks

Honesty Kim,
Grace Hu,
Austin J. Graham,
Grace X. Gu,
and Zev J. Gartner

Cold Spring Harb Perspect Biol November 25, 2024;a041557 First published online November 25, 2024 doi:10.1101/cshperspect.a041557

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Telomeres and Telomerase Telomere Dynamics in Human Health and Disease

Duncan M. Baird

Cold Spring Harb Perspect Biol November 25, 2024;a041701 First published online November 25, 2024 doi:10.1101/cshperspect.a041701

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Translating and Retranslating Mendelism The Significance of Mendelism for Evolutionary Theory: A Reassessment

Samir Okasha

Cold Spring Harb Perspect Biol November 25, 2024;a041837 First published online November 25, 2024 doi:10.1101/cshperspect.a041837

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Translating and Retranslating Mendelism Plant Breeding and the Origins of Genetics

Nils Roll-Hansen

Cold Spring Harb Perspect Biol November 25, 2024;a041714 First published online November 25, 2024 doi:10.1101/cshperspect.a041714

November 5, 2024

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Translating and Retranslating Mendelism Teaching School Genetics in the 2020s: Why “Naive” Mendelian Genetics Has to Go

Kostas Kampourakis

Cold Spring Harb Perspect Biol November 5, 2024;a041679 First published online November 5, 2024 doi:10.1101/cshperspect.a041679

September 30, 2024

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Glia Role of Microglia in Central Nervous System Development and Plasticity

Dorothy P. Schafer,
Beth Stevens,
Mariko L. Bennett,
and Frederick C. Bennett

Cold Spring Harb Perspect Biol September 30, 2024;a041810 First published online September 30, 2024 doi:10.1101/cshperspect.a041810

September 16, 2024

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Glia Glial Malignancies

Suzanne J. Baker,
Hui Zong,
and Michelle Monje

Cold Spring Harb Perspect Biol September 16, 2024;a041373 First published online September 16, 2024 doi:10.1101/cshperspect.a041373

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Glia The Biology of Glia

Beth Stevens,
Kelly R. Monk,
and Marc R. Freeman

Cold Spring Harb Perspect Biol September 16, 2024;a041809 First published online September 16, 2024 doi:10.1101/cshperspect.a041809

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Glia Glia in Neurodegenerative Disease

Gerard Crowley,
David Attwell,
Hemali Phatnani,
Harald Sontheimer,
and Soyon Hong

Cold Spring Harb Perspect Biol September 16, 2024;a041375 First published online September 16, 2024 doi:10.1101/cshperspect.a041375

August 12, 2024

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Glia Glial Origins of Inherited White Matter Disorders

Anjana Sevagamoorthy,
Adeline Vanderver,
Jamie L. Fraser,
and Jennifer Orthmann-Murphy

Cold Spring Harb Perspect Biol August 12, 2024;a041457 First published online August 12, 2024 doi:10.1101/cshperspect.a041457

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Skeletal Muscle Biology Autophagy in Skeletal Muscle

Anais Franco-Romero,
Marco Sandri,
and Stefano Schiaffino

Cold Spring Harb Perspect Biol August 12, 2024;a041565 First published online August 12, 2024 doi:10.1101/cshperspect.a041565

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Glia Cellular Contributions to Glymphatic and Lymphatic Waste Clearance in the Brain

Leon C.D. Smyth,
Natalie Beschorner,
Maiken Nedergaard,
and Jonathan Kipnis

Cold Spring Harb Perspect Biol August 12, 2024;a041370 First published online August 12, 2024 doi:10.1101/cshperspect.a041370

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Skeletal Muscle Biology The Myotendinous Junction—Form and Function

Abigail L. Mackey

Cold Spring Harb Perspect Biol August 12, 2024;a041500 First published online August 12, 2024 doi:10.1101/cshperspect.a041500

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Skeletal Muscle Biology The Diversity of Skeletal Muscle Fiber Types

Stefano Schiaffino,
Francesco Chemello,
and Carlo Reggiani

Cold Spring Harb Perspect Biol August 12, 2024;a041477 First published online August 12, 2024 doi:10.1101/cshperspect.a041477

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Glia The Nodes of Ranvier: Mechanisms of Assembly and Maintenance

Matthew N. Rasband and
Elior Peles

Cold Spring Harb Perspect Biol August 12, 2024;a041361 First published online August 12, 2024 doi:10.1101/cshperspect.a041361

July 22, 2024

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Evolution and Development of Neural Circuits Interneuron Diversity: How Form Becomes Function

Natalia V. De Marco García and
Gord Fishell

Cold Spring Harb Perspect Biol July 22, 2024;a041513 First published online July 22, 2024 doi:10.1101/cshperspect.a041513

July 15, 2024

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Evolution and Development of Neural Circuits Modeling Normal and Abnormal Circuit Development with Recurrent Neural Networks

Daniel Zavitz,
ShiNung Ching,
and Geoffrey Goodhill

Cold Spring Harb Perspect Biol July 15, 2024;a041507 First published online July 15, 2024 doi:10.1101/cshperspect.a041507

June 10, 2024

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Developmental Dynamics: Guided Morphogenesis and Self-Organization across Scales Mechanochemical Principles of Epidermal Tissue Dynamics

Carien M. Niessen,
M. Lisa Manning,
and Sara A. Wickström

Cold Spring Harb Perspect Biol June 10, 2024;a041518 First published online June 10, 2024 doi:10.1101/cshperspect.a041518

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