周伯琦（1298年 - 1369年），字伯温，饶州人，周应极的儿子。元代官员、书法家。曾任南海县主簿，后升为翰林院修撰。元顺帝至正元年，由修撰特例拜为宣文阁授经郎、鉴书博士，转经筵官、崇文监丞，以南人出身而于至正十二年四月由翰林直学士、兵部侍郎拜监察御史，陪同皇帝巡幸上都。其升转的原由则是当年二月下达的圣旨，禁止任官时的种族歧视现象。伯琦特别擅长篆书，为当时篆书名家。曾在元仁宗时期的宣文阁供职，受到书法家康里巙巙的赞扬。据杨士奇的记载，巙巙称：「周伯琦篆书，今世无过之者。」其篆书作品《相鹤经》今藏于国立故宫博物院。

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Zhou Boqi 周伯琦 (1298–1369) was a Chinese court poet during the Yuan Dynasty. Zhou was born in Raozhou (now Boyang) but grew up in Beijing, and in his early career worked there as a magistrate and later as Senior Compiler for Imperial Academy. He was well known for his seal script calligraphy.