Aggregation of huntingtin protein with an expanded polyglutamine region is enhanced by its 17-residue N-terminal ___domain, which binds to itself and to the polyglutamine region. This enhancement is inhibited when the N-terminal ___domain binds to the chaperonin TRiC.
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Liebman, S., Meredith, S. Protein folding: Sticky N17 speeds huntingtin pile-up. Nat Chem Biol 6, 7–8 (2010). https://doi.org/10.1038/nchembio.279
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DOI: https://doi.org/10.1038/nchembio.279
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