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The Role of Geography in Human Adaptation

Figure 2

The relationship between mean F_ST and the most extreme allele frequency differences genome-wide between pairs of HGDP populations.

The x-axis of each plot shows the autosomal mean F_ST for pairs of HGDP populations, considering all possible pairs from among the 26 HGDP populations with samples of ≥15 individuals. The y-axes show the value of (A) the maximum autosomal allele frequency difference () for each population pair, and (B) the value of the 65th most extreme for each population pair (i.e., the 99.99th percentile of the allele frequency distribution). To provide a sense of scale on the figure, red arrows are used to indicate the mean autosomal pairwise F_ST between some arbitrary pairs of populations (key: French (Fra), Palestinian (Pal), Han-Chinese (Han) and Yoruba (Yor)). The red lines plot lowess fits to the data. Plots of the extremes of pairwise F_ST and with different sample size cutoffs are similar (Supplementary Figures 5 and 6 in Text S1).

doi: https://doi.org/10.1371/journal.pgen.1000500.g002