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Chemical Constituents from Achyranthes bidentata and Their Antihyperuricemic Acid Activities

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One new coumaronochromone named 5,7,2′-trihydroxy-6-methoxycoumaronochromone (1), and six known compounds named benzyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (2), chikusetsusaponin V (3), crotonine (4), ayamenin A (5), achyranthoside A (6), 5-hydroxypyridine-2-carboxylic acid methyl ester (7), were obtained from Achyranthes bidentata. The antihyperuricemic acid activities of these isolated compounds (1–7) were assayed by an HK-2 cell model induced by adenosine combined with xanthine oxidase. The contents of uric acid produced by the HK-2 cell model were determined by HPLC analysis. As the results show, compound 3 was the most effective and was almost in line with the positive drug of febuxostat, whereas compounds 1, 4, 5, and 6 showed moderate antihyperuricemic acid activities at a concentration of 50.0 μM.

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Acknowledgment

This work was supported by the Key R&D Program of Shandong Province, China (2021ZDSYS12), China Agriculture Research System of MOF and MARA (CARS-21), and National Science & Technology Fundamental Resources Investigation Program of China (2018FY100700).

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Authors and Affiliations

  1. Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), 250014, Jinan, P. R. China

    Jinqian Yu, Xiao Wang, Hongjing Dong & Wei Liu

  2. Key Laboratory for Natural Active Pharmaceutical Constituents Research in Universities of Shandong Province, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), 250014, Jinan, P. R. China

    Jinqian Yu, Xiao Wang, Hongjing Dong & Wei Liu

  3. S. Yu. Yunusov Institute of the Chemistry of Plant Substance, Academy of Science of the Republic of Uzbekistan, 77 M. Ulugbek Street, 100170, Tashkent, Uzbekistan

    E. Kh. Botirov & S. D. Gusakova

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  1. Jinqian Yu
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Correspondence to Wei Liu.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2025, pp. 49–51.

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Yu, J., Wang, X., Botirov, E.K. et al. Chemical Constituents from Achyranthes bidentata and Their Antihyperuricemic Acid Activities. Chem Nat Compd 61, 52–55 (2025). https://doi.org/10.1007/s10600-025-04572-y

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  • DOI: https://doi.org/10.1007/s10600-025-04572-y

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