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Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
Bioactive lipid mediators (LMs) derived from polyunsaturated fatty acids (PUFAs) are key molecules in both the initiation and resolution of...
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East Antarctic tectonic basin structure and its implications for ice-sheet modeling and sea-level projections
The volume of the East Antarctica Ice Sheet is equivalent to ~52 m of sea-level rise, but whether the ice sheet is a major contributor to global...
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Transforming US agriculture for carbon removal with enhanced weathering
Enhanced weathering (EW) with agriculture uses crushed silicate rocks to drive carbon dioxide removal (CDR)
1 ,2 . If widely adopted on farmlands, it...
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Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction
Aging of the brain vasculature plays a key role in the development of neurovascular and neurodegenerative diseases, thereby contributing to cognitive...
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Cognitive functioning in children and adolescents with cerebral palsy: protocol for the Danish CPCog-Youth study
BackgroundMany children and adolescents with cerebral palsy (CP) experience cognitive difficulties, impacting their academic, social, and emotional...
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Tension at the gate: sensing mechanical forces at the blood–brain barrier in health and disease
Microvascular brain endothelial cells tightly limit the entry of blood components and peripheral cells into the brain by forming the blood–brain...
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Ontogeny shapes individual dietary specialization in female European brown bears (Ursus arctos)
Individual dietary specialization, where individuals occupy a subset of a population’s wider dietary niche, is a key factor determining a species...
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An intranasal cationic liposomal polysaccharide vaccine elicits humoral immune responses against Streptococcus pneumoniae
Diseases caused by S. pneumoniae are the leading cause of child mortality. As antibiotic resistance of S. pneumoniae is rising, vaccination remains...
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An in situ depot for the sustained release of a TLR7/8 agonist in combination with a TGFβ inhibitor promotes anti-tumor immune responses
Cancer curing immune responses against heterogeneous solid cancers require that a coordinated immune activation is initiated in the antigen avid but...
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Inflammation-induced TRPV4 channels exacerbate blood–brain barrier dysfunction in multiple sclerosis
BackgroundBlood–brain barrier (BBB) dysfunction and immune cell migration into the central nervous system (CNS) are pathogenic drivers of multiple...
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Multicentre, randomised controlled trial of physiological-based cord clamping versus immediate cord clamping in infants with a congenital diaphragmatic hernia (PinC): statistical analysis plan
BackgroundInfants born with congenital diaphragmatic hernia (CDH) are at high risk of respiratory insufficiency and pulmonary hypertension. Routine...
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Improving the performance of cryogenic calorimeters with nonlinear multivariate noise cancellation algorithms
State-of-the-art physics experiments require high-resolution, low-noise, and low-threshold detectors to achieve competitive scientific results....
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Deep Generative Models for Fast Photon Shower Simulation in ATLAS
The need for large-scale production of highly accurate simulated event samples for the extensive physics programme of the ATLAS experiment at the...
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Nachhaltige Entwicklungsziele und die Kreislaufwirtschaft: Bewertung von Handlungsoptionen
The UN 2030 Agenda for Sustainable Development offers a plan of action for people, planet and prosperity. It also seeks to strengthen universal peace...
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Endothelial cells and macrophages as allies in the healthy and diseased brain
Diseases of the central nervous system (CNS) are often associated with vascular disturbances or inflammation and frequently both. Consequently,...
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Sjögren’s disease activity associates with cardiovascular disease and monoclonal gammopathy: a university cohort study of disease activity and comorbidities
BackgroundWe used the University of Wisconsin cohort to determine the extent to which the EULAR Sjögren’s syndrome disease activity index (ESSDAI)...
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Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans
Skin color is highly variable in Africans, yet little is known about the underlying molecular mechanism. Here we applied massively parallel reporter...
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Directed Circularization of a Short RNA
Basic research and functional analyses of circular RNA (circRNA) have been limited by challenges in circRNA formation of desired length and sequence...
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Acute Nontraumatic Imaging in the Liver and Spleen
Each year, more than 120 million patients visit the emergency room in the USA. The single most common cause of presentation in the emergency room...