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Isolation of biologically active peptides from the venom of Japanese carpenter bee, Xylocopa appendiculata
BackgroundMass spectrometry-guided venom peptide profiling is a powerful tool to explore novel substances from venomous animals in a highly sensitive...
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Novel polyacetylene derivatives and their inhibitory activities on acetylcholinesterase obtained from Panax ginseng roots
In our research program to identify cholinesterase and β-secretase inhibitors, we investigated Ginseng (root of Panax ginseng ), a crude drug...
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Screening of β-secretase and acetylcholinesterase inhibitors from plant resources
The therapeutic agents for dementia are limited due to the complex system underlying the mechanisms. Taking a preventive point of view, we focused on...
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Effect of Morinda citrifolia fruit extract and its iridoid glycosides on blood fluidity
The aim of this study was to investigate the effect of Morinda citrifolia fruit on blood fluidity. M. citrifolia fruit extract (MCF-ext) was...
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Effects of ginsenosides on the expression of cytochrome P450s and transporters involved in cholesterol metabolism
An extract from red ginseng (steamed and dried roots of Panax ginseng C.A. Meyer; RGE) has been shown to promote cholesterol metabolism in the liver....
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Improvement in blood fluidity by Kaempferia parviflora rhizome
Improvement in blood fluidity leads to the prevention of various lifestyle-related diseases. A raw material for improving blood fluidity has been...
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Increased effects of ginsenosides on the expression of cholesterol 7α-hydroxylase but not the bile salt export pump are involved in cholesterol metabolism
An extract from red ginseng [steamed and dried roots of Panax ginseng C.A. Meyer (RGE)] has been shown to have various actions on physiological...
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Anti-degranulating activity in rat basophil leukemia RBL-2H3 cells of flavanone glycosides and their aglycones in citrus fruits
The anti-degranulating activity of flavonoids present in Citrus fruits was comprehensively evaluated. Among these, hesperetin and naringenin,...
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Inhibitory activities of Puerariae Flos against testosterone 5α-reductase and its hair growth promotion activities
Crude drugs expected to have an estrogenic effect were screened for their inhibitory activity on testosterone 5α-reductase. Testosterone 5α-reductase...
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Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells
Mangiferin, 1,3,6,7-tetrahydroxyxanthone-C2-β- d -glucoside (C-glucosylxanthone), is a xanthone derivative that is widely distributed in higher plants....
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Inhibitory effects of devil’s claw (secondary root of Harpagophytum procumbens) extract and harpagoside on cytokine production in mouse macrophages
Successive oral administration (50 mg/kg) of a 50% ethanolic extract (HP-ext) of devil’s claw, the secondary root of Harpagophytum procumbens , showed...
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Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice
Oral administration of a 50% ethanolic extract (CH-ext) obtained from unripe Citrus hassaku fruits collected in July exhibited a potent...
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Saponin fraction from Astragalus membranaceus roots protects mice against polymicrobial sepsis induced by cecal ligation and puncture by inhibiting inflammation and upregulating protein C pathway
Sepsis remains the leading cause of death in intensive care units. Uncontrolled systemic inflammation and an impaired protein C pathway are two...
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Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle
The screening of Piperaceous plants for xanthine oxidase inhibitory activity revealed that the extract of the leaves of Piper betle possesses potent...
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Inhibitory effects of constituents of Morinda citrifolia seeds on elastase and tyrosinase
A 50% ethanolic extract (MCS-ext) from seeds of Morinda citrifolia (“noni” seeds) showed more potent in vitro inhibition of elastase and tyrosinase,...
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Anti-allergic effect of a combination of Citrus unshiu unripe fruits extract and prednisolone on picryl chloride-induced contact dermatitis in mice
Effect of 50% ethanolic extract of unripe fruits of Citrus unshiu (CU-ext) on type IV allergic reaction was examined by inhibitory activity of ear...
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Preparation and properties of oligoesterified wood blocks based on anhydride and epoxide
Preparation and properties of oligoesterified woods in the form of block are reviewed. The oligoesterified wood blocks are prepared by stepwise...
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Complexation of Lanthanoids with 4-(2-Thiazolylazo)-6-bromoresorcinol
4-(2-Thiazolylazo)-6-bromoresorcinol (TAR-Br) was synthesized and its usefulness for spectrophotometric determination of 14 tanthanoid(lll) ions was...