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High Hcy regulates fluid shear stress pathway activity through histone H3K79 homocysteinylation in hyperhomocysteinemia-related child hypertension
BackgroundThe rise of hypertension in children has been increasingly associated with hyperhomocysteinemia (HHcy), which is recognized as a major risk...
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Comparison of oscillatory activity in substantia nigra pars reticulata between Parkinson’s disease and dystonia
Parkinson’s disease (PD) is associated with disrupted neural activity in the substantia nigra, but its electrophysiological changes remain...
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A four-state reverse current active fault diagnosis method for cascaded H-bridge multilevel inverter
Multilevel inverters are prospective in high-voltage and high-power applications because of their low harmonics and high efficiency. Open-circuit...
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Applications of Carbon-Based Multivariable Chemical Sensors for Analyte Recognition
Over recent decades, carbon-based chemical sensor technologies have advanced significantly. Nevertheless, significant opportunities persist for...
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The impact of decreased SIRT1 levels on pediatric primary hypertension and left ventricular hypertrophy: a case-control study
BackgroundDecreased SIRT1 exhibits a correlation with a range of cardiovascular diseases. However, the changes in serum SIRT1 levels in pediatric...
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Investigating the association between polyunsaturated fatty acids and osteomyelitis by Mendelian randomization
Osteomyelitis, characterized by bone inflammation and infection, poses a significant global health burden. This Mendelian randomization (MR) study...
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Renal artery branch stenosis induced hypertension in children: a case series
PurposeRenal artery branch stenosis induced hypertension (HTN) in children is rare and facing a great challenge in diagnosis and treatment. This...
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FTO controls CD8+ T cell survival and effector response by modulating m6A methylation of Fas
Functional CD8 + T cell immunity is essential for immune surveillance and host defense against infection and tumors. Epigenetic mechanisms,...
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Scalp block improves electrophysiological stability and patient cooperation during deep brain stimulation surgery
Deep Brain Stimulation (DBS) is a critical intervention for various neurological disorders. While effective, the traditional local infiltration...
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Revealing the Oxidative Stress-Related Molecular Characteristics and Potential Therapeutic Targets of Schizophrenia through Integrated Gene Expression Data Analysis
Schizophrenia is a severe mental disorder characterized by oxidative stress imbalances. The underlying mechanisms of oxidative stress-related gene...
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Oral FPR2/ALX modulators tune myeloid cell activity to ameliorate mucosal inflammation in inflammatory bowel disease
Current treatments of inflammatory bowel disease (IBD) largely depend on anti-inflammatory and immunosuppressive strategies with unacceptable...
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Diversity of intestinal microbiota and inflammatory cytokines after severe trauma
Accumulating evidence has reported that the intestinal microbiota could play important roles in the occurrence and progression of severe trauma....
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Preliminary experience of combined dual plasma molecular adsorption system and plasma exchange in pediatric acute liver failure: a retrospective case series
BackgroundPediatric acute liver failure (PALF) is a life-threatening condition with no definitive treatment. This study evaluated the combined use of...
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Multi-interface engineering of FeS2/C/MoS2 with core–shell structure for superior microwave absorption performance
Heterojunction and morphology control assume a significant part in adjusting the intrinsic electromagnetic properties of absorbers to acquire...
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Matrix moment approach to positivity bounds and UV reconstruction from IR
Positivity bounds in effective field theories (EFTs) can be extracted through the moment problem approach, utilizing well-established results from...
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Experimental and Numerical Study of Multi-Energy Low-Velocity Impact and Compression-After-Impact Damage Mechanism of 3D Woven Composites
Carbon fiber fabric composites as a multiphase material have excellent mechanical properties such as high specific modulus, stable performance, and...
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Pathogenesis of influenza and SARS-CoV-2 co-infection at the extremes of age: decipher the ominous tales of immune vulnerability
The co-circulation of influenza and SARS-CoV-2 has led to co-infection events, primarily affecting children and older adults, who are at higher risk...
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Coronary health index based on immunoglobulin light chains to assess coronary heart disease risk with machine learning: a diagnostic trial
BackgroundRecent studies suggest a connection between immunoglobulin light chains (IgLCs) and coronary heart disease (CHD). However, current...
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Dissecting casual effects of diet on the risk of inflammatory bowel disease and the potential mediation by gut microbiota: a Mendelian randomization study
BackgroundDiet plays a fundamental role in maintaining intestinal health. Here, we investigated whether there is the causal association of diet with...
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Plasma fibronectin is a prognostic biomarker of disability in Parkinson’s disease: a prospective, multicenter cohort study
In a prospective longitudinal study with 218 Parkinson’s disease (PD) patients in the discovery cohort and 84 in the validation cohort, we aimed to...