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Binding studies of promethazine and its metabolites with human serum albumin by high-performance affinity chromatography and molecular docking in the presence of codeine
“Purple Drank”, a soft drink containing promethazine (PMZ) and codeine (COD), has gained global popularity for its hallucinogenic effects. Consuming...
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Chiral Analysis with Mass Spectrometry Detection in Food and Environmental Chemistry
The challenge to develop enantioselective analytical methods to quantify chiral compounds in food and environmental matrices is an actual and...
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Assessment of effluents quality through ecotoxicological assays: evaluation of three wastewater treatment plants with different technologies
The water quality of the effluents is mainly focused on physicochemical and microbiological parameters. However, the ecotoxicological assessments are...
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Spatiotemporal Distribution and Sources of Trace Elements in Ave River (Portugal) Lower Basin: Estuarine Water, Sediments and Indigenous Flora
This study aimed to assess the spatial and seasonal distribution and anthropogenic sources of trace elements (Li, Be, Al, V, Cr, Co, Ni, Cu, Zn, Se,...
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Chiral enantioresolution of cathinone derivatives present in “legal highs”, and enantioselectivity evaluation on cytotoxicity of 3,4-methylenedioxypyrovalerone (MDPV)
Recently, great interest has been focused on synthetic cathinones since their consumption has increased exponentially. All synthetic cathinones exist...
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Priority Substances and Emerging Organic Pollutants in Portuguese Aquatic Environment: A Review
Aquatic environments are among the most noteworthy ecosystems regarding chemical pollution due to the anthropogenic pressure. In 2000, the European...
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Occurrence of Natural Contaminants of Emerging Concern in the Douro River Estuary, Portugal
Many studies demonstrated the presence of diverse environmental contaminants in the Douro River estuary, such as natural and synthetic estrogens,...
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Small Molecules as Chromatographic Tools for HPLC Enantiomeric Resolution: Pirkle-Type Chiral Stationary Phases Evolution
This review focuses on the evolution of Pirkle-type chiral stationary phases (CSPs), based on chiral recognition mechanism of small molecules and...
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Enantioselective HPLC analysis and biodegradation of atenolol, metoprolol and fluoxetine
The accurate quantification of enantiomers is crucial for assessing the biodegradation of chiral pharmaceuticals in the environment. Methods to...
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Environmental Fate of Chiral Pharmaceuticals: Determination, Degradation and Toxicity
Pollution of the aquatic environment by pharmaceuticals is of major concern. Indeed pharmaceutical pollutants have several undesirable effects for...
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Spatial distribution and quantification of endocrine-disrupting chemicals in Sado River estuary, Portugal
The important Portuguese Sado River estuary has never been investigated for the presence of potentially endocrine-disrupting chemicals (EDCs), such...
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Seasonal and Spatial Distribution of Several Endocrine-Disrupting Compounds in the Douro River Estuary, Portugal
Recent studies in the Douro River estuary show signs of pollution in the area and of fish endocrine disruption. However, the chemical nature of the...
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Distribution of endocrine disruptors in the Mondego River estuary, Portugal
Recent studies in the Mondego River estuary demonstrated signs of pollution in the area, but the nature of the contamination remains unexplored....