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The concepts and origins of cell mortality
Organismal death is foundational to the evolution of life, and many biological concepts such as natural selection and life history strategy are so...
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The Ancient Origins of Death Domains Support the ‘Original Sin’ Hypothesis for the Evolution of Programmed Cell Death
The discovery of caspase homologs in bacteria highlighted the relationship between programmed cell death (PCD) evolution and eukaryogenesis. However,...
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The Nature of Programmed Cell Death
In multicellular organisms, cells are frequently programmed to die. This makes good sense: cells that fail to, or are no longer playing important...
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Evolution of cytokinesis-related protein localization during the emergence of multicellularity in volvocine green algae
BackgroundThe volvocine lineage, containing unicellular Chlamydomonas reinhardtii and differentiated multicellular Volvox carteri , is a powerful...
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The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity
The transition to multicellularity has occurred numerous times in all domains of life, yet its initial steps are poorly understood. The volvocine...
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Robust sequence alignment using evolutionary rates coupled with an amino acid substitution matrix
BackgroundSelective pressures at the DNA level shape genes into profiles consisting of patterns of rapidly evolving sites and sites withstanding...
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Multicolour flow cytometry analyses and autofluorescence in chlorophytes: lessons from programmed cell death studies in Chlamydomonas reinhardtii
Flow cytometry is a valuable tool in phycological studies. However, endogenous cellular compounds like nicotinamide adenine dinucleotide and...
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Evolutionary rates at codon sites may be used to align sequences and infer protein ___domain function
BackgroundSequence alignments form part of many investigations in molecular biology, including the determination of phylogenetic relationships, the...
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An analysis of mobile genetic elements in three Plasmodium species and their potential impact on the nucleotide composition of the P. falciparum genome
BackgroundThe completed genome sequences of the malaria parasites P. falciparum , P. y. yoelii and P. vivax have revealed some unusual features. P....
