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Laparoscopic peritoneal lavage versus sigmoidectomy for perforated diverticulitis with purulent peritonitis: three-year follow-up of the randomised LOLA trial
BackgroundThis study aimed to compare laparoscopic lavage and sigmoidectomy as treatment for perforated diverticulitis with purulent peritonitis...
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Pharmacogenomics characterization of the MDM2 inhibitor MI-773 reveals candidate tumours and predictive biomarkers
MI-773 is a recently developed small-molecule inhibitor of the mouse double minute 2 (MDM2) proto-oncogene. Preclinical data on the anti-tumour...
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Impact of the COVID-19 pandemic on incidence and severity of acute appendicitis: a comparison between 2019 and 2020
BackgroundDuring the COVID-19 pandemic, a decrease in the number of patients presenting with acute appendicitis was observed. It is unclear whether...
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Plasma markers in pulmonary hypertension subgroups correlate with patient survival
BackgroundRecent studies have provided evidence for an important contribution of the immune system in the pathophysiology of pulmonary arterial...
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Enhanced PeriOperative Care and Health protection programme for the prevention of surgical site infections after elective abdominal surgery (EPO2CH): statistical analysis plan of a randomised controlled multicentre superiority trial
BackgroundSurgical site infections (SSI) are frequent complications after elective abdominal surgery. We designed the Enhanced PeriOperative Care and...
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Estimates of female genital mutilation/cutting in the Netherlands: a comparison between a nationwide survey in midwifery practices and extrapolation-model
BackgroundOwing to migration, female genital mutilation or cutting (FGM/C) has become a growing concern in host countries in which FGM/C is not...
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Sarcoidosis and Work Participation: The Need to Develop a Disease-Specific Core Set for Assessment of Work Ability
ObjectiveSarcoidosis, an inflammatory multi-organ disease with a wide variety of clinical manifestations, affecting people of working age. Patients...
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Correction to: The Burden of Sarcoidosis Symptoms from a Patient Perspective
The original version of this article unfortunately contained a mistake in coauthor's given name. The abbreviated given name "M.D." for coauthor...
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The Burden of Sarcoidosis Symptoms from a Patient Perspective
PurposeThe clinical manifestations of sarcoidosis vary widely, depending on the intensity of the inflammation and the organ systems affected. Hence,...
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Fibrocytes are increased in lung and peripheral blood of patients with idiopathic pulmonary fibrosis
BackgroundFibrocytes are implicated in Idiopathic Pulmonary Fibrosis (IPF) pathogenesis and increased proportions in the circulation are associated...
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Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative
Background:The European NCI compounds programme, a joint initiative of the EORTC Research Branch, Cancer Research Campaign and the US National Cancer...
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Biomarkers for Prostate Cancer
In the last decade, revolutionary advancements in molecular profiling technologies resulted in new diagnostic algorithms. These advances have marked...
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Blood-based and urinary prostate cancer biomarkers: a review and comparison of novel biomarkers for detection and treatment decisions
BACKGROUND:The diagnosis of prostate cancer (PCa) is currently based on serum PSA testing and/or abnormal digital rectal examination and...
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Large area photonic flash soldering of thin chips on flex foils for flexible electronic systems: In situ temperature measurements and thermal modelling
In this work photonic energy from a high power xenon flash lamp is used for soldering thin chips on polyimide and polyester foil substrates using...
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How do gut feelings feature in tutorial dialogues on diagnostic reasoning in GP traineeship?
Diagnostic reasoning is considered to be based on the interaction between analytical and non-analytical cognitive processes. Gut feelings, a specific...
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Basal Ca2+ signaling is particularly increased in mutated chronic lymphocytic leukemia
On the basis of somatic hypermutation status of their B-cell antigen receptor (BCR) genes, chronic lymphocytic leukemia (CLL) patients can be divided...
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The impact of QoS differentiation on service quality and system capacity in cellular networks
Mobile network operators are currently preparing the introduction of QoS differentiation mechanisms in their 3G networks, as a means to support...
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Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity
The adapter protein Slp65 and Bruton's tyrosine kinase (Btk) are key components of the precursor-B (pre-B) cell receptor (pre-BCR) signaling pathway....
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Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma
Background:Suppressive immune cells present in tumour microenvironments are known to augment tumour growth and hamper efficacy of antitumour...
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Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK
X-linked agammaglobulinemia (XLA) is the most common primary immunodeficiency (PID) in man and caused by mutations in the Bruton’s tyrosine kinase ( BTK...
