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A comparative study of the effect of carbon nanomaterials on the thermophysical and mechanical properties of perfluoroelastomers: molecular dynamics simulation
This study employs perfluoroelastomers (FFKM) as the matrix material, with graphene, carbon nanotubes, hydroxyl-functionalized graphene (OH-GNS), and...
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APOE4 impairs macrophage lipophagy and promotes demyelination of spiral ganglion neurons in mouse cochleae
The ApoE-ε4 gene is a well-established genetic risk factor for neurodegenerative diseases, such as Alzheimer’s disease and multiple sclerosis, which...
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Integrating direct anthropogenic disturbances and habitat connectivity to guide the restoration of the Amur tiger population in a newly established national park in China
ContextChina initiated its national parks in 2016 for safeguarding biodiversity and ecosystem integrity. The newly established Northeast Tiger and...
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Oral pH-Sensitive Solid Self-Microemulsion of Norcantharidin Wrapped in Colon-Coated Capsule for Selective Therapy of Colorectal Carcinoma
Due to the poor solubility, permeability, stability and tumor-targeting ability of norcantharidin (NCTD), currently commercially available NCTD...
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Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression
BackgroundTumor-associated macrophages (TAMs), particularly M2-polarized TAMs, are significant contributors to tumor progression, immune evasion, and...
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Spatiotemporal patterns of small carnivores in a human-dominated forest landscape shared with apex predators
ContextRapid increases in human population and the resulting apex predator defaunation are affecting the spatial and temporal dynamics of small...
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Baicalein induces apoptosis by targeting ribosomes in Candida auris
The emergence of the “super fungus” Candida auris poses a significant threat to human health, given its multidrug resistance and high mortality...
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Mechanical and tribological properties of fluororubber enhanced by three carbon nanomaterials at a high temperature: A molecular simulation approach
Fluororubber (FKM), known for its high-temperature resistance and mechanical deformation capabilities, is extensively used in the aerospace and...
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Suppressing the virulence factors of Candida auris with baicalein through multifaceted mechanisms
Candida auris , a rapidly spreading multi-drug‐resistant fungus, is causing lethal infections under certain conditions globally. Baicalin (BE), an...
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Feature-based point cloud simplification method: an effective solution for balancing accuracy and efficiency
Traditional point cloud simplification methods are slow to process large point clouds and prone to losing small features, which leads to a large loss...
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Oxysterol 25-hydroxycholesterol activation of ferritinophagy inhibits the development of squamous intraepithelial lesion of cervix in HPV-positive patients
Squamous intraepithelial lesion of cervix (SIL) in human papillomavirus (HPV)-positive patient often undergoes a silent and long-course development,...
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Scalable Optimal Formation Path Planning for Multiple Interconnected Robots via Convex Polygon Trees
A Reconfigurable Modular Robotic System (RMRS) consists of multiple interconnected robots and can achieve various functionalities by rearranging its...
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When dual contrastive learning meets disentangled features for unpaired image deraining
As the basis work of image processing, rain removal from a single image has always been an important and challenging problem. Due to the lack of real...
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Transjugular Intrahepatic Portosystemic Shunt Benefits for Hepatic Sinusoidal Obstruction Syndrome Associated with Consumption of Gynura Segetum: a Propensity Score-Matched Analysis
PurposePyrrolidine alkaloids-related hepatic sinusoidal obstruction syndrome (PA-HSOS) is associated with a high mortality rate without standardized...
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Deciphering the pharmacological mechanisms of Fraxini Cortex for ulcerative colitis treatment based on network pharmacology and in vivo studies
BackgroundUlcerative colitis (UC) is a common type of inflammatory bowel disease. Due to the elusive pathogenesis, safe and effective treatment...
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Contributions of distemper control and habitat expansion to the Amur leopard viability
The Amur leopard ( Panthera pardus orientalis ) is a critically endangered top predator that struggles on the brink of extinction due to threats such...
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Modular transfer learning with transition mismatch compensation for excessive disturbance rejection
Underwater robots in shallow waters usually suffer from strong wave forces, which may frequently exceed robot’s control constraints. Learning-based...
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Persistent ferroptosis promotes cervical squamous intraepithelial lesion development and oncogenesis by regulating KRAS expression in patients with high risk-HPV infection
Cervical squamous cell carcinoma (CSCC) is a type of female cancer that affects millions of families worldwide. Human papillomavirus (HPV) infection...
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Research on Blockchain Privacy Protection Mechanism in Financial Transaction Services Based on Zero-Knowledge Proof and Federal Learning
In the financial transaction system centering on blockchain technology, institutions at different levels have different powers and roles, so that...
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Systems pharmacology and transcriptomics reveal the mechanisms of Sanhuang decoction enema in the treatment of ulcerative colitis with additional Candida albicans infection
BackgroundUlcerative colitis (UC) is an important inflammatory phenotype in bowel disease (IBD), which is caused by multiple potential factors,...
