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Development and validation of betel-year: a clinical tool for quantifying exposure to betel quid chewing, utilizing nuclear morphometric analysis and validated by cytomorphological analysis
BackgroundBetel quid chewing, prevalent in Southeast Asia and South Asia, involves components such as betel leaf, areca nut, slaked lime, and...
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A rare case of betel nut-associated oral squamous cell carcinoma in the United States: a case study
IntroductionOral squamous cell carcinoma (OSCC) poses a significant global public health challenge, accounting for more than 90% of oral...
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Large-scale structural covariance networks changes relate to executive function deficit in betel quid-dependent chewers
Previous studies demonstrate deficits in executive function for betel quid-dependent (BQD) patients. Large-scale structural covariance network (SCN)...
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Rising incidence of HPV positive oropharyngeal cancer in Taiwan between 1999 and 2014 where betel nut chewing is common
BackgroundThe incidence of human papillomavirus (HPV) positive oropharyngeal cancer (OPC) is rising but HPV negative OPC is decreasing in Western...
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Incidence trends of oral cavity, oropharyngeal, hypopharyngeal and laryngeal cancers among males in Taiwan, 1980–2019: a population-based cancer registry study
In a country with a high prevalence of cigarette smoking, betel chewing, and alcohol drinking, cancers of the oral cavity, nasopharynx, and larynx...
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A Novel Green Synthesis Method for the Preparation of Highly Fluorescent Carbon Dots for Security Ink Applications
Environmentally benign biosynthesized carbon dots with diverse chemical and physical properties play an important role in today’s scientific...
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Findings from a Malaysian multicentre study on oropharyngeal squamous cell carcinoma
BackgroundIn addition to the conventional aetiologic agents of oropharyngeal squamous cell carcinoma (OPSCC) such as tobacco usage, alcohol...
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Combined effect of areca nut, cigarettes, alcohol and SNPs in glycosyltransferase family genes on lung cancer development in Hainan, China
BackgroundAbnormal glycosylation modification is closely related to the development and metastasis of cancers. As a carcinogen by the International...
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A multivariate pattern analysis of resting-state functional MRI data in Naïve and chronic betel quid chewers
Betel quid (BQ) is the fourth most commonly consumed psychoactive substance in the world. However, comprehensive functional magnetic resonance...
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Areca nut-induced metabolic reprogramming and M2 differentiation promote OPMD malignant transformation
BackgroundBetel quid and its major ingredient, areca nut, are recognized by IARC as major risk factors in oral cancer development. Areca nut extract...
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Processing and Potential Health Benefits of Betel Leaf (Piper betle L.)
The Piper betle is a woody, perennial and climbing vine belonging to the family Piperaceae. The fresh leaves of betel vine, generally known as Paan...
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Assessment of multiple mycotoxin exposure and its association with food consumption: a human biomonitoring study in a pregnant cohort in rural Bangladesh
Aflatoxins (AFs), ochratoxin A (OTA), citrinin (CIT), fumonisin B1 (FB1), zearalenone (ZEN), and deoxynivalenol (DON) are mycotoxins that may...
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Effects of smokeless tobacco on cancer incidence and mortality: a global systematic review and meta-analysis
IntroductionThe prevalence of smokeless tobacco consumption remains high despite policies on reduction interventions. This study aims to quantify the...
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Harnessing State-of-the-Art Gene Therapy to Transform Oral Cancer Treatment
Oral cancer, the most prevalent type of cancer in the head and neck region, has an overall five-year survival rate of less than 50%. Key risk factors...
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Mutational signatures and mutagenic impacts associated with betel quid chewing in oral squamous cell carcinoma
Betel quid (BQ) chewing is a prevailing risk for oral squamous cell carcinoma (OSCC) in Southeast Asia. Yet, the detailed mechanisms by which BQ...
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DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing—a possible predictive biomarker for malignant transformation
BackgroundDNA hypermethylation of tumor suppressor genes is observed in precancerous lesions and oral cancer of individuals with the habits of betel...
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Association between sleep problems and impulsivity mediated through regional homogeneity abnormalities in male methamphetamine abstainers
Sleep problems and impulsivity frequently occur in methamphetamine (MA) abstainers and are linked to aberrant brain function. However, the interplay...
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Influence of psoriasis on infection risk and survival outcomes in patients with head and neck cancer: a retrospective cohort study
BackgroundPsoriasis is a chronic inflammatory skin condition mediated by autoimmune processes, which may heighten the susceptibility to infections....
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Prognostic factors and risk-stratification model of recurrent or metastatic head and neck squamous cell carcinoma treated with cetuximab containing regimen
BackgroundIn recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and...
