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Preparation, characterization, oral bioavailability, and pharmacodynamic study of eugenol-porous silica solidified powder
Eugenol possesses anti-inflammatory and antioxidant properties, and may serve as a potential therapeutic agent for hepatic fibrosis. However, the...
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The antihypertensive effect of the coadministration of exercise and eugenol in deoxycorticosterone acetate-induced hypertension in rats
Hypertension (HTN) is a significant health issue with high morbidity, especially in the cardiovascular system, leading to mortality. HTN could be...
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Eugenol attenuates aluminium-induced neurotoxicity in rats by inhibiting the activation of STAT3 and NF-кB
Aluminium is a common metallic toxicant that easily penetrates the brain and exerts severe pathological effects e.g., oxidative stress, inflammation...
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Eugenol-Loaded Transethosomal Gel for Improved Skin Delivery and Treatment of Atopic Dermatitis
AbstractAtopic dermatitis is a skin condition characterized by lichenification (thickening and increased skin marking), eczematous lesions, dry skin,...
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Targeting cardiovascular risk factors with eugenol: an anti-inflammatory perspective
Inflammation is a multifaceted biological reaction to a wide range of stimuli, and it has been linked to the onset and progression of chronic...
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Mitigation of Trypanosoma congolense-Associated Anemia and Expression of Trans-sialidase (TconTS) Gene Variants by Eugenol
PurposeAfrican Animal Trypanosomosis (AAT) caused by Trypanosoma congolenseis a parasitic disease affecting the livestock industry in sub-Saharan...
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Do combinations of fipronil, eugenol and carvacrol have synergistic effects against Rhipicephalus sanguineus?
The tick Rhipicephalus sanguineusis one of the main ectoparasites that affects dogs, causing direct and indirect damage to parasitized animals....
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The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action
This study was designed to assess the ameliorative effects of eugenol and to propose the possible mechanisms of action of eugenol in...
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RND pump inhibition: in-silico and in-vitro study by Eugenol on clinical strain of E. coli and P. aeruginosa
Multidrug-resistant (MDR) gram-negative bacteria pose significant challenges to the public health. Various factors are involved in the development...
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Anticoccidial activity of a botanical natural product based on eucalyptus, apigenin and eugenol against Eimeria tenella in broiler chickens
BackgroundChicken coccidiosis is an intracellular parasitic disease that presents major challenges to the development of the commercial poultry...
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Enhanced Stability and Solidification of Volatile Eugenol by Cyclodextrin-Metal Organic Framework for Nasal Powder Delivery
Eugenol (Eug) holds potential as a treatment for bacterial rhinosinusitis by nasal powder drug delivery. To stabilization and solidification of...
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Synthesis, trypanocidal and cytotoxic activities of α,β-unsaturated ketones derived from eugenol and analogues
This work describes the synthesis, structural characterization, trypanocide and cytotoxic evaluation of α,β-unsaturated ketones derived from eugenol...
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Fabrication and Evaluation of Anticancer Potential of Eugenol Incorporated Chitosan-Silver Nanocomposites: In Vitro, In Vivo, and In Silico Studies
The expanding global cancer burden necessitates a comprehensive strategy to promote possible therapeutic interventions. Nanomedicine is a...
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Antimicrobial Activity of Bioactive Compounds (Thymoquinone and Eugenol) and Its Nanoformulation Therapeutic Potential
Plants are the unique source of bioactive compounds. Microbial infections like bacterial, viral, parasitic, and fungal are very common worldwide. The...
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Methyl eugenol protects the kidney from oxidative damage in mice by blocking the Nrf2 nuclear export signal through activation of the AMPK/GSK3β axis
Disrupted redox homeostasis contributes to renal ischemia–reperfusion (IR) injury. Abundant natural products can activate nuclear factor...
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Eugenol, a Component of Holy Basil (Tulsi) and Common Spice Clove, Inhibits the Interaction Between SARS-CoV-2 Spike S1 and ACE2 to Induce Therapeutic Responses
Spike S1 of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) on host cells to enter the...
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Recent advances in chemical reactivity and biological activities of eugenol derivatives
Eugenol (4-allyl-2-methoxyphenol) is a volatile phenolic bioactive compound derived from a natural resource. This compound has been identified in...
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Eugenol and Other Vanilloids Hamper Caenorhabditis elegans Response to Noxious Heat
Eugenol, a known vanilloid, was frequently used in dentistry as a local analgesic in addition, antibacterial and neuroprotective effects were also...
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Antinociceptive Activity of Vanilloids in Caenorhabditis elegans is Mediated by the Desensitization of the TRPV Channel OCR-2 and Specific Signal Transduction Pathways
Vanilloids, including capsaicin and eugenol, are ligands of transient receptor potential channel vanilloid subfamily member 1 (TRPV1). Prolonged...
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Molecular mechanisms of antiproliferative and pro-apoptotic effects of essential oil active constituents in MCF7 and T24 cancer cell lines: in vitro insights and in silico modelling of proapoptotic gene product-compound interactions
This study aims to investigate the in vitro antiproliferative and pro-apoptotic/apoptotic potential of active constituents of essential oils on two...
