Interesting, I take risankizumab, which looks like it indirectly suppresses IL-17 (through suppressing IL-23A). I've been on it for a bit less than a year, and I can't say if I've had improved mood. Maybe? It definitely fixed the psoriasis. Might also have contributed to me getting sick more often, though.
I wish I had kept logs with some sort of self-screen depression instrument now (maybe the BDI? I don't like the PHQ-9). Might as well start now.
Recent risankizumab convert here :) Definitely happier now than I was before starting, but I'm sure some of that comes from the Crohn's not ruling my entire life anymore, lol. [knocks furiously on wood]
But I didn't know about the indirect IL-17 suppression. That's interesting!
I'm irked in general by the lack of attention given to solar time. If I ever get into Android hacking, it'll be so I can replace the system statusbar clock with a solar one.
I'm somewhat puzzled why so much attention is given to solar time. Why is it so important to have 12:00 be noon and match the time of day the sun is at its peak?
I'd much rather use UTC everywhere and eliminate daylight saving time. Because I'm currently UTC-5, it means the average workday would be 13:00 to 22:00, and
noon becomes 17:00, but that seems no less arbitrary than 08:00 to 17:00 and 12:00, respectively.
Local noon (when the sun crosses the local meridian) orients us in time and in space. In time, because it marks the day being half-over. In space, because you can use solar alignment to lay out buildings and other structures in a north-south direction, or simply to navigate your locale.
It signifies a good time to eat lunch and the proper direction to orient your belly for an afternoon nap in the sun. :)
One of my screens at work is a full-screen UTC clock with seconds. But I added the solar altitude (in degrees) to the bottom of the display, just so I could easily track how close I am to sunrise or sunset. Solar azimuth would be more clock-like and make it obvious when the sun was culminating, but there's lots you can do when you program your own dashboards.
Really neat, thank you for posting. I took a different angle when trying to figure this out - my goals were high spectral similarity to the sun, high brightness, adjustable warmth, and low cost. The existing lower-cost solutions people have posted about end up with high brightness, but the lights are evil.
I ended up with a photography light that's /alright/. It's not nearly as bright as I want, and I can't automate changing the warmth. When I next take a crack at this, I'll look deeper into some of what you've posted about here.
This sapling is twice as large as it was a week ago, which was twice again as large as it was the week before. Why, at this rate, it'll be bigger than the whole world in but a month.
T: What's happening with this sausages, Charlie?
C: 2 minutes, Turkish.
-- 5 Minutes later ---
T: How long for the sausages?
C: 5 minutes, Turkish.
T: It was 2 minutes, 5 minutes ago.
I don't know why I remembered it. Is it AI, or self driving cars, or both. Huh.
self driving cars are here, just unevenly distributed. Waymo operates in several cities already, providing millions of rides to people. Just because you haven't seen them doesn't mean they don't exist.
Waymo operates in tiny parts of several cities when you look at the maps. They didn't finish the first 90% when you look from that perspective.
Waymo provides a tech demonstrator in a closed circuit, and you can pay to ride their demonstrators in select areas of select cities. It's not half bad, let's be honest, but having these limits puts them to a point very far from "self driving cars are here". Even Tesla isn't there with their camera only subsystems and "if you crash you keep both pieces" policy. It's another tech demonstrator you can buy.
If we accept your point that "self driving cars are here", we should accept that Fusion energy is a solved problem because WEST tokamak held plasma for 22 minutes, electric propulsion is a solved problem since we have electric trains for a long time, and Hyperloop is fully operational because I have scale model in my backyard which carries thousands of ants every day.
People open their phone, order a car, take a ride from an arbitrary point within the geofenced area, to another arbitrary point inside that area. Within that area. they're handling real life conditions. dogs and children running into the street, bicyclists, moving trucks blocking streets, construction. Other cars. Maybe that's not enough for you, but that's not a carefully staged tech demo with a car driving a loop around a fixed track at Disneyland that's gonna break the moment it has to deviate beyond what you're allowed to touch. Unless you think Waymo is paying all the drivers in LA drivers to drive different around their cars, I guess.
If the tokomak was energy positive for those 22 minutes, there was more than one of them, and they were running it multiple times a day then I would say it is. But it's not. I'm not sure why you have this need to lump them together. Fusion is quite a different problem, with yet to be solved materials science problems and control systems issues. I'm not claiming that fusion's here, and also I don't think quantum computers are gonna be here anytime soon.
Yeah, call me a cynic or conservative or whatever - I'll believe it when I see it. I give very little weight to predictions about the future from AI shills, especially when they include some variant of "we're 90% there already" or "an exponential shift is imminent, if things keep improving at this rate, which they Will." Opinion discarded, create your thing and come back if/when it works.
Everything is shifting so fast right now that it hardly matters anyways. Whatever I spend time learning will be outdated in a few years (when things are predicted to get good). It does matter if you're trying to sell AI products, though. Then you gotta convince people they're missing out, their livelihood is at stake if they don't use your new thing now now now.
I think it is possible to acknowledge that privilege, while still highlighting the things that suck for us, and the ways unions can help. I wish the article did this. I firmly believe there is a strong case to be made here. It gets muffled by the narrowness of the author's perspective.
I've worked in a kitchen and a warehouse for a while, I absolutely know how good we've got it. I have friends who tell me about people dying at their workplaces. Pretty much everyone I know who's not a programmer is living paycheck-to-paycheck. I'm still incredibly burnt out, and probably couldn't continue for another 6 months if my life depended on it.
Probably because programmers aren't generally also social workers, who help people like this day in and day out, with essential local context. Source: my partner does social work, I'm a programmer, and I'm now aware of how little I know here.
Great, thanks. I would have valued your post more if you'd stated this. Unfortunately it just looked like you said "All these people are idiots and I'm right".
having fun with this. I like the longer runs better but it feels kind of crowded, I wonder if you could optimize for fewer+longer? also just had the thought you could fit this into arbitrary bounding shapes, not just a square...
completed the day's puzzle! it's a bit hard to keep the runs in my head. what if instead of run lines, the polygons had a background, like stripes for one run, checkers for another, and half/half for ones with both? I don't think this idea is quite right, but it might spark something from someone else..
I'm colorblind, which may have something to do with how hard it was to keep track of the runs. maybe they could be kept as lines, but with some as dashes, some dots, some solid, etc?
I wish I had kept logs with some sort of self-screen depression instrument now (maybe the BDI? I don't like the PHQ-9). Might as well start now.