Academia.edu no longer supports Internet Explorer.
To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to upgrade your browser.
2018
AI
This research analyzes Gothic graffiti from the early Byzantine basilica at Mangup, revealing insights into the use and evolution of the Gothic language in the region. The findings indicate that Gothic inscriptions were prevalent as late as the 9th-10th centuries, demonstrating a linguistic coexistence with Greek and a strong influence of Byzantine practices in their composition. The study highlights the significance of these inscriptions in understanding the linguistic landscape of the Crimean Goths and their connection to the wider Gothic cultural tradition.
Church № 4 from the Murfatlar rock complex - some newly documented graffiti along the east-west axis and their analogies, 2023
The occasion for yet another archaeological documentation in the research history of the Murfatlar rock monastery was provided by the continuous excavations (2005-2010) of one particular site in Pliska-the so called Round stone platform. Its rediscovery occurred a decade later in relation to a special study focused on the graffiti incised on 2% of the building material, most of which are invisible to the naked eye and convey Christian symbols, personages and scenes of Biblical character. These circumstances brought the research team to the most certain (and best preserved) possible analogy-the rock monastic complex of Murfatlar, in Constanţa County, Romania. The subject of this paper are the graffiti along the east-west axes in Church № 4. The photographic documentation of April 2022 attempted to cover with maximum precision all carvings, especially the shallowest ones and those that are practically invisible to the naked eye. As long as a drawing of this graffito has not been published so far, it can be said now that the so far unknown details in it are: additions and/or thorough corrections of the two Cyrillic inscriptions, as well as two rune-like inscriptions. We have completed full photographic and graphic visualization of the images, with details of the two human figures and that of the bird.
Pontica, 2023
The occasion for yet another archaeological documentation in the research history of the Murfatlar rock monastery was provided by the continuous excavations (2005-2010) of one particular site in Pliska-the so called Round stone platform. Its rediscovery occurred a decade later in relation to a special study focused on the graffiti incised on 2% of the building material, most of which are invisible to the naked eye and convey Christian symbols, personages and scenes of Biblical character. These circumstances brought the research team to the most certain (and best preserved) possible analogy-the rock monastic complex of Murfatlar, in Constanţa County, Romania. The subject of this paper are the graffiti along the east-west axes in Church № 4. The photographic documentation of April 2022 attempted to cover with maximum precision all carvings, especially the shallowest ones and those that are practically invisible to the naked eye. As long as a drawing of this graffito has not been published so far, it can be said now that the so far unknown details in it are: additions and/or thorough corrections of the two Cyrillic inscriptions, as well as two rune-like inscriptions. We have completed full photographic and graphic visualization of the images, with details of the two human figures and that of the bird.
Archaeologia Bulgaricа, 2024
Two hitherto unknown Cyrillic graffiti are presented in this article. The one discussed first, is a two-line long textual graffiti, an autograph of “[God’s] servant Gregory”. This graffiti has been dated to the second half of the tenth century AD. The language, orthography and paleography of this textual graffiti have many similarities with contemporary graffiti from northeastern Bulgaria. The second Cyrillic graffiti is a four-line long prayer. It has been dated to between the thirteenth and the fourteenth century AD. The language, orthography and paleography of this textual graffiti belong to the area of east Slavonic Cyrillic literacy. The text contains a reading of these textual graffiti, as well as analysis of the language, orthography, paleography, and genre affiliation. The investigation has also resulted in new knowledge on the agents of these graffiti, that is, the persons who scratched these graffiti.
Нумизматика, Сфрагистика и Епиграфика, 2023
The subject of the present article is an inscribed marble pedestal found in 2005 during archaeological excavations of an Early Byzantine basilica in Dolnoto Gradishte locality near the village of Mikrevo, Strumyani Municipality (Southwestern Bulgaria). The monument consists of a foundation and a Tuscan base. It was made in the late 1 st or in the early 2 nd century AD and was most probably an element of the architectural environment of a military camp. In the late 2 nd century it was reused as a pedestal upon which it may be assumed that an ostotheke (ash chest) was placed. A six-line Greek inscription was engraved on the front side. It is a funerary inscription dedicated by Artemidora to the memory of her son and husband with a value of 300 denarii.
The article considers a group of monuments of Christian architecture located in the northeastern part of the Black Sea region, the least studied archaeologically. In the Byzantine era, the southern part of Krasnodar region of the Russian Federation was the northern part of Abkhazia, which in the church relation was subordinate to the Patriarch of Constantinople. Ten churches of the 6 th-11 th centuries, which are in a state of ruins, have been studied here. They belong to different architectural types: two basilicas, two domed churches, one cross-shaped and five one-nave churches. Several architectural fragments testify to buildings unknown to us. The most important domed churches (Loo, Vesyoloe) closely followed the Byzantine tradition, other structures differed in local features, for example, the Lesnoe basilica 1. Many features of the churches examined reveal their proximity to the architectural monuments of neighboring Abkhazia and Alania, also closely connected with Byzantium.
Proceedings of the 23rd International Congress of Byzantine Studies - Thematic sessions of free communications, 2016
The authenticity and dating of the well-known Cyrillic inscription from Bitola, which was brought to light in 1956 during the demolition of Çavus mosque, where it had been placed in second use as a threshold, is being reviewed. Since then, it has been kept at the local museum. It consists of a 0,98 x 0,61 x 0,27 m. marble slab, broken into two pieces. A relatively small part of the bottom left corner of the inscription is missing. The text consists of 12 lines with missing letters both at the beginning and at the end of each line. The bottom left part which accounts for one quarter of the inscription text has been damaged and no traces of its letters have survived. Although the inscription is of exceptional interest, the first study that attempted to fill in the missing text, was carried out by Vladimir Mošin only one decade after it was brought to light. Since, it has been the subject of studies of numerous researchers. Most of them reckon that the inscription is the last written source of the First Bulgarian State with an accurate dating, while others question this view and argue that it dates from the 13th century. According to a third view that was expressed ten years ago, the inscription is falsified. The most extensive study about the inscription was conducted in 1970 by Jordan Zaimov, who had a different view than Mošin about the missing text. Even though his suggestion was deemed unfounded, it is still embraced today by modern researchers in publications about the history of the First Bulgarian State. After an on-the-ground examination of the monument, we found out that the inscription carrier originates from an older building, most likely from the Roman era, as evidenced from the top narrow surface of the marble, where there are holes and channels to fit Π-shaped metal joints. This contradicts the view that the inscription could have had another line on the top side of the inscribed surface, which was allegedly removed when it was placed in the place of the threshold. We also found out that the indicated date from the creation era (‘anno mundi’) was not read correctly despite the fact that all its numbers are clearly defined. It seems that the inscription editors were led to a mistake because of a reference made in the text to an emperor called John whom they mistook for Ivan Vladislav thus placing the dating of the inscription to the years of his reign (1015- 1018). Nonetheless, the year indicated on the inscription corresponds to the year 1202/3, i.e. the years of Ivan I, known as Kalojan (1197-1207), who, that same year, annexed to his acquisitions a large part of the western Balkans. It seems that it is an inscription that, looking back at the past, mentions some historical events with a view to connecting the newly-established Second Bulgarian State to the glorious past of the Cometopuli and, in particular, Tsar Samuel.
As part of a project to compile all published and unpublished Greek and Latin inscriptions in the Karadeniz Ereğli Museum into a corpus, inscriptions were copied and worked on with the permission of the Ministry of Culture and Tourism’s General Directorate of Culture Heritage and Museums. These inscriptions are all from Zonguldak Region (Ereğli, Çaycuma/Filyos, Devrek, Gökçebey, Kilimli, Alaplı). In this article, ten previously unpublished Greek funerary inscriptions are presented: eight of them are from ancient Heraclea Pontica and its territorium (Ereğli, Alaplı), and two are from the ancient city of Tios (Tieion, Filyos). All are dated to the Roman Imperial period. SEG 59-1440-1441. Tios/Tieion. Epitaphs, Imperial period. 1. SEG 59 1440 — Epitaph of Senianos. 2. SEG 59 1441 — Epitaph of an unknown person. Edd.pr. B.Öztürk, I.F.Sönmez, Arkeoloji ve Sanat 132 (2009) 135 no. 7 (ph.) and 136 no. 10 (ph.), publish the following texts now in the Museum in Ereğli. Date 1st century AD - Imperial period SEG 59 1440 — Epitaph of Senianos. 135 no. 7. Epitaph of Senianos. Large 1 white marble statue base moulded above and below; on top a recess for a statue/bust. Greek text also in An.Ép. (2009) [2012] no. 1357. Inscription Σενιανὸς | Μηνιανοῦ | ζήσας κοσ|μείως ‖ ἔτη κα΄· | χαῖρε Apparatus criticus 1. First attestation of the Latin name Senianus (Celtic origin), edd.pr. 2. Μηνιανοῦ: equivalent of the Latin cognomen Menianus, edd.pr. [J.-Y.Strasser in An.Ép.prefers Minianus, possibly related to Μηνίας with Latin suffix, Pleket]. SEG 59-1447-1454. Herakleia Pontike. Epitaphs. (1,578 words) Article Table Of Contents 1. SEG 59 1447 — Epitaph of Dionysios, Imperial period. 2. SEG 59 1448 — Epitaph of Herakleitos, Imperial period. 3. SEG 59 1449 — Epitaph of Iulia, Imperial period. 4. SEG 59 1450 — Epitaph of Chrysa/e, Imperial period. 5. SEG 59 1451 — Epitaph of Chrysea, Imperial period. 6. SEG 59 1452 — Epitaph of Olympichos, Imperial period. 7. SEG 59 1453 — Epitaph of Tryphosa, Imperial period. 8. SEG 59 1454 — Epitaph of Xenios, 123 A.D. Edd.pr. B.Öztürk, I.F.Sönmez, Arkeoloji ve Sanat 132 (2009) 129-135 nos. 1-6 and 135/136 nos. 8/9, publish the following epitaphs, now in the Museum in Ereğli (ph.; English translation). SEG 59 1447 — Epitaph of Dionysios, Imperial period. 130 no. 1. Epitaph of Dionysios, Imperial period. White marble stele; in a recessed arched field a standing male figure clad in a himation and holding his right arm on his chest. Inscription Διον̣ύσιος Ἡρα|κλέωνος ἐτῶ̣ν | ξ΄ vv· χαῖρε Apparatus criticus 2nd cent./first half of the 3rd cent. A.D., edd.pr. [without arguments; the letter forms do not allow a more specific dating than ‘Imperial period’, Pleket]. Inscription metadata SEG 59 1448 — Epitaph of Herakleitos, Imperial period. 130/131 no. 2. Epitaph of Herakleitos, Imperial period. White marble stele with pediment and akroteria; in the pediment a rosette; in a recessed field a representation of a standing boy clad in a chlamys, holding a pigeon in his left and grapes in his right hand; in a corner a dog eating from the grapes. Inscription Ἡράκλειτος Ἡρακλείτο̣υ νήπιος Apparatus criticus 2nd cent. A.D. (on the basis of the letter forms), edd.pr., who adduce various other reliefs and propose that the child figure is to be defined as Dionysos or Eros. Inscription metadata Date 1st century AD - Imperial period SEG 59 1449 — Epitaph of Iulia, Imperial period. 133 no. 3. Epitaph of Iulia, Imperial period. White marble stele; below the inscription in a slightly recessed field a seated woman clad in chiton and himation; Greek text also in An.Ép.(2009) [2012] no. 1368. Inscription [Ἰ]ο̣υλία, Ἡ[ρακ]λ̣είδου̣ θυ̣|γά̣?τηρ, ἐτῶ̣ν ιγ΄· χαῖρε Date 1st century AD - Imperial period SEG 59 1450 — Epitaph of Chrysa/e, Imperial period. 133 no. 4. Epitaph of Chrysa/e, Imperial period. White marble stele with pediment and akroteria; in the pediment a rosette; in a recessed field a representation of a seated woman clad in chiton and himation, and of a basket; in front of the woman and the basket a small standing female servant; in the lower left corner a small male servant; L. 1 above, LL. 2/3 below the relief; from Alaplı (territory of Herakleia). Inscription Χρύσε Μίκκου θυγάτηρ, | γυνὰ δὲ Φιλίππ[ου], | ἐτῶν v ξ΄ v · χαῖρε Apparatus criticus 1. Χρύσε = Χρύση or Χρύσα, edd.pr. Inscription metadata Date 1st century AD - Imperial period SEG 59 1451 — Epitaph of Chrysea, Imperial period. 133 no. 5. Epitaph of Chrysea, Imperial period. White marble stele with pediment and akroteria; in a recessed field a representation of a woman clad in chiton and himation and lying on a couch; in her left hand a phiale; in front of the couch a table; inscription above the relief: Inscription Χρυσέα, Τωλα θυγάτηρ, ἐτῶν π΄· | χαῖρε Apparatus criticus 1. Τωλα, gen. of Τωλας, previously unattested, edd.pr. Date 1st century AD - Imperial period SEG 59 1452 — Epitaph of Olympichos, Imperial period. 135 no. 6. Epitaph of Olympichos, Imperial period. White marble stele; in a recessed field a representation of a man clad in chiton and himation and lying on a couch; in front of the couch a table, an ox and, outside the recessed field, a male servant; inscription on the band above the relief: Inscription Ὀλύμ̣πιχο[ς] Ὀλυ[μ]|πίχο⟨υ⟩ ἐτῶ̣ν κε΄· | χαῖρε Date 1st century AD - Imperial period SEG 59 1453 — Epitaph of Tryphosa, Imperial period. 135/136 no. 8. Epitaph of Tryphosa, Imperial period. White marble stele with pediment and akroteria; in a recessed field a representation of a standing woman clad in a chiton with a himation over her head; in the lower right corner a small servant; inscription above the relief; from Alaplı (territory of Herakleia). Inscription [Τρ]υφῶσα ῾Ηρακλείτου | ἐτῶν πε΄· | χαῖρε Date 1st century AD - Imperial period SEG 59 1454 — Epitaph of Xenios, 123 A.D. 136 no. 9. Epitaph of Xenios, 123 A.D. White marble stele with pediment and akroteria; in the pediment a rosette; in a recessed field a representation of a man clad in a chiton, lying on a couch and holding an aryballos in his left hand; on the left a seated woman clad in a chiton with a himation over her head; in front of the couch a table and in the right and left lower corners two smaller standing figures: a male and a female servant, clad in a himation and in a chiton and himation, respectively; inscription below the relief. Inscription Ξένιος, Μενάδρου | υἱός, ἐτῶν κγ΄· | χαῖρε· | ἔτους δνρ΄, Γωρπιαίου̣ βι΄ Apparatus criticus [1. Μενάδρου for Μενάνδρου, Pleket] 4. year 154 = 123 A.D. (Aktian era), edd.pr.
2009
In rail track environments, the loading system is cyclic unlike the steady seepage force that usually occurs in embankment dams. The mechanisms of filtration, interface behaviour, and time dependent changes of the drainage and filtration properties occurring within the filter medium require further research to improve the design guidelines. A novel cyclic process simulation filtration apparatus was designed and commissioned at the University of Wollongong, and a standard test procedure was established. The test apparatus was designed to simulate heavy haul train operations. The key parameters that influence the change in porosity and pore water pressure within the subballast layer under cyclic conditions in rail track environments were identified. Crushed basaltic road base was used as the filter subballast. The slurry form of the base soil, which is a low plasticity and highly erodible silty clay, was pumped from the bottom of the filter to simulate clay pumping and hydraulic erosion. Grading characteristics such as the uniformity coefficient and the mass of fines, and the external loading factors such as the maximum compressive load and slurry loading rate, were found to be the main factors that influence the mechanical characteristics and seepage hydraulics of subballasts under cyclic conditions. The evidence gathered from laboratory testing suggests that the subballast selection criteria adopted by the railway industry, which are based on mathematical and empirical models generated from static load conditions in embankment dams, does not address the filtration mechanism of subballasts under cyclic conditions. Apart from being a commonly used buffer for the ballast layer against subgrade attrition, subballast is primarily designed to act as a stress dissipation layer (capping layer) and its function as a filter is often regarded as a lesser priority. With more emphasis on the stress reduction function, well graded subballast containing larger particles provides a better skeletal resistance against applied stresses. However, well graded subballasts containing relatively coarse grains (20% fine sand, 30% fine gravel) are too porous to effectively Abstract vi capture the fines within its voids. Laboratory findings suggested that uniformly graded subballasts with not more than 30% fine sands (particle range of 0.15 to 0.425 mm) had an enhanced filtering capacity. Due to the lack of mechanical resistance against axial deformation, the application of cyclic stress to uniformly graded subballasts reduces porosity and enables the filter to trap migrating fines more effectively. Moreover, this intrusion of fines changes the PSD of the subballast which reduces its porosity and further inhibits drainage. A multi-layer mathematical approach was used to predict the time dependent permeability of this filter, with (a) a reduction in porosity as a function of compression under cyclic loading, and (b) the amount of fines trapped within the filter voids, being the two main aspects of this proposed model. Laboratory test results conducted on a novel cyclic loading permeameter were used to validate the proposed model. The set of equations that forms an integral part of the proposed model is then presented as compact visual guidelines anticipated to provide a more practical tool for railway practitioners.
Transfusion, 2020
Background/Case Studies: Stem cells derived in vitro production of platelets provide an alternative to major clinical problems of donor-dependent supply, alloimmunization and limited shelf life. However, such efforts are often limited to generate platelets in scales required for platelet transfusion. Hence our aim was to identify and understand molecular mechanisms of platelet production that will enable greater yields of megakaryocytes (MKs) and platelets in vitro. Study Design/Methods: RNAs from purified platelets and laser-captured bone marrow MKs from healthy
2014
6.7. Research Question 4-Are there any differences between students" teaching and learning in public schools and private schools in terms of their use of ICT in the classroom? 6.8. Research Question 5-Are there any differences between male and female students" teaching and learning in terms of their use of ICT in the classroom? 7 Conclusions and Recommendations 7.1. Introduction 7.2. Research Question 1-How confident are teachers in using ICT in the teaching and learning process? 7.3. Research Question 2-Does this confidence and application vary between subjects? 7.4. Research Question 3-How do students use ICT in the classroom and at home? 7.5. Research Question 4-Are there any differences between students" teaching and learning in public schools and private schools in terms of their use of ICT in the classroom? 7.6. Research Question 5-Are there any differences between male and female students" teaching and learning in terms of their use of ICT in the classroom? 7.7. Recommendations 7.8.
2008
for challenging me as a scholar and supporting me as a student. I wish to acknowledge and thank the anti-mascot scholars whose work has inspired me to produce something that provides additional credence for the cause. Particularly, I want to express my gratitude to Robert Eurich, whose American Indian Sports Team Mascots website (www.aistm.org) kept me informed with news regarding the struggle to eliminate Indigenous-based team names and mascots. I am also indebted to many people at the University of Nebraska, including John Wunder, Victoria
2002
This report focuses on recent trends in the food supply chain. Chapters on food manufacturing, wholesaling, grocery retailing, and food service provide a detailed overview of structure, performance, information systems, new technology, and foreign direct investments. The report also contains a comprehensive set of appendix tables containing sales, concentration, trade, productivity, and other indicators. At the time of publication, most of the data sets used in this report included data through the year 2000.
2010
Preface Named Entities play a significant role in Natural Language Processing and Information Retrieval. While identifying and analyzing named entities in a given natural language is a challenging research problem by itself, the phenomenal growth in the Internet user population, especially among the non-English speaking parts of the world, has extended this problem to the crosslingual arena. We specifically focus on research on all aspects of the Named Entities in our workshop series, Named Entities WorkShop (NEWS). The first of the NEWS workshops (NEWS 2009) was held as a part of ACL-IJCNLP 2009 conference in Singapore, and the current edition (NEWS 2010) is being held as a part of ACL 2010, in Uppsala, Sweden. The purpose of the NEWS workshop is to bring together researchers across the world interested in identification, analysis, extraction, mining and transformation of named entities in monolingual or multilingual natural language text. The workshop scope includes many interesting specific research areas pertaining to the named entities, such as, orthographic and phonetic characteristics, corpus analysis, unsupervised and supervised named entities extraction in monolingual or multilingual corpus, transliteration modelling, and evaluation methodologies, to name a few. For this years edition, 11 research papers were submitted, each of which was reviewed by at least 3 reviewers from the program committee. 7 papers were chosen for publication, covering main research areas, from named entities recognition, extraction and categorization, to distributional characteristics of named entities, and finally a novel evaluation metrics for co-reference resolution. All accepted research papers are published in the workshop proceedings. This year, as parts of the NEWS workshop, we organized two shared tasks: one on Machine Transliteration Generation, and another on Machine Transliteration Mining, participated by research teams from around the world, including industry, government laboratories and academia. The transliteration generation task was introduced in NEWS 2009. While the focus of the 2009 shared task was on establishing the quality metrics and on baselining the transliteration quality based on those metrics, the 2010 shared task expanded the scope of the transliteration generation task to about dozen languages, and explored the quality depending on the direction of transliteration, between the languages. We collected significantly large, hand-crafted parallel named entities corpora in dozen different languages from 8 language families, and made available as common dataset for the shared task. We published the details of the shared task and the training and development data six months ahead of the conference that attracted an overwhelming response from the research community. Totally 7 teams participated in the transliteration generation task. The approaches ranged from traditional unsupervised learning methods (such as, Phrasal SMT-based, Conditional Random Fields, etc.) to somewhat unique approaches (such as, DirectTL approach), combined with several model combinations for results re-ranking. A report of the shared task that summarizes all submissions and the original whitepaper are also included in the proceedings, and will be presented in the workshop. The participants in the shared task were asked to submit short system papers (4 pages each) describing their approach, and each of such papers was reviewed by at least two members of the program committee to help improve the quality of the content and presentation of the papers. 6 of them were finally accepted to be published in the workshop proceedings (one participating team did not submit their system paper in time). NEWS 2010 also featured a second shared task this year, on Transliteration Mining; in this shared task we focus specifically on mining transliterations from the commonly available resource Wikipedia titles. The objective of this shared task is to identify transliterations from linked Wikipedia titles between English and another language in a non-Latin script. 5 teams participated in the mining task, each participating in multiple languages. The shared task was conducted in 5 language pairs, and the paired iii Wikipedia titles between English and each of the languages was provided to the participants. The participating systems output was measured using three specific metrics. All the results are reported in the shared task report. We hope that NEWS 2010 would provide an exciting and productive forum for researchers working in this research area. The technical programme includes 7 research papers and 9 system papers (3 as oral papers, and 6 as poster papers) to be presented in the workshop. Further, we are pleased to have
2019 IEEE 19th International Conference on Bioinformatics and Bioengineering (BIBE), 2019
The goal of this work is to improve proteotypic peptide prediction with lower processing time and better efficiency. Proteotypic peptides are the peptides in protein sequence that can be confidently observed by mass-spectrometry based proteomics. One of the widely used method for identifying peptides is tandem mass spectrometry (MS/MS). The peptides that need to be identified are compared with the accurate mass and elution time (AMT) tag database. The AMT tag database helps in reducing the processing time and increases the accuracy of the identified peptides. Prediction of proteotypic peptides has seen a rapid improvement in recent years for AMT studies for peptides using amino acid properties like charge, code, solubility and hydropathy. We describe the improved version of a support vector machine (SVM) classifier that has achieved similar classification sensitivity, specificity and AUC on Yersinia Pestis, Saccharomyces cerevisiae and Bacillus subtilis str. 168 datasets as was described by . The improved version of the SVM classifier uses the C++ SVM library instead of the MATLAB built in library. We describe how we achieved these similar results with much lesser processing time. Furthermore, we tested four machine learning classifiers on Yersinia Pestis, Saccharomyces cerevisiae and Bacillus subtilis str. 168 data. We performed feature selection from scratch, using four different algorithms to achieve better results from the different machine learning algorithms. Some of these classifiers gave similar or better results than the SVM classifiers with fewer features. We describe the results of these four classifiers with different feature sets. v Preface This MS thesis is written as completion of my research work at the University of South Carolina. I started to work on this project one year ago with Prof. Dr. John Rose with great enthusiasm. I took this project to learn how to apply different machine learning techniques to a given problem. By working on this project I was introduced to the world of proteomics. I learned about identification of peptides and how it helps in identification of proteins. In Chapter 2, I describe the data preparation methodology to prepare the proteotypic and non-proteotypic dataset. I have used the datasets available at National Center for Biotechnology Information, MassIVE (University of California at San Diego) and Global Proteome Machine Database (GPMDB) to prepare our dataset. In data preparation, I appreciate all the help I got from Jeremy Lane. In Chapter 3, I have improved on the support vector classifier (SVM) described by Ahmed Alqurri [11] and Web Robertson et al. [15]. In Chapter 4, I performed different feature selection algorithms from scratch without considering much of previous work. In Chapter 5, I have implemented different machine learning classifiers using feature sets from Chapter 4. In Chapter 3, 4, and 5, I have used Yersinia Pestis and Saccharomyces cerevisiae datasets to perform machine learning algorithms. In Chapter 6, I have improved on the classification models described in Chapter 5. In Chapter 6, I have added Bacillus subtilis str. 168 dataset prepared in Chapter 2 to further test our models. vi
2012
The transport of compounds around the body has been a topic of interest for many years, and the advent of non-invasive biological imaging in living tissue has made huge advances in the characterisation and localisation of cellular receptors for use in drug targeting. However, there remains a significant paucity of knowledge regarding how the majority of drug molecules are transported about the body, when they often exhibit negligible aqueous solubility and the body expresses no trans-membrane pumps or chaperone proteins that recognise them and facilitate their movement. This leads to large attrition rates in drug discovery programmes, as compounds with high binding constants or inhibitive activity in vitro fail to perform in vivo, due to poor bioavailability or non-specific sequestration away from the tissue of interest. In this study, the interactions between a number of drug and lipid molecules were investigated and the effects upon both the lipids' chemical and bulk membrane ...