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Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle

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Abstract

The screening of Piperaceous plants for xanthine oxidase inhibitory activity revealed that the extract of the leaves of Piper betle possesses potent activity. Activity-guided purification led us to obtain hydroxychavicol as an active principle. Hydroxychavicol is a more potent xanthine oxidase inhibitor than allopurinol, which is clinically used for the treatment of hyperuricemia.

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Acknowledgments

The authors are grateful to Prof. Ih-Sheng Chen at Kaohsiung Medical University in Taiwan for a valuable discussion. This work was financially supported by the “Antiaging Center Project” for Private Universities from Ministry of Education, Culture, Sports, Science and Technology, 2008–2012.

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Authors and Affiliations

  1. School of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan

    Kazuya Murata, Noriko Hirata, Kensuke Namba & Hideaki Matsuda

  2. Research Institute of Oriental Medicine, Kinki University, 377-2 Ohno-higashi, Osakasayama, Osaka, 589-8511, Japan

    Kikuyo Nakao, Kenzo Moriyama & Takahiro Shintani

  3. Nichinichi Pharmaceutical Co., Ltd., 239-1 Tominaga, Iga, Mie, 518-1417, Japan

    Takao Nomi & Yoshihisa Kitamura

  4. Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu, 502-8585, Japan

    Munekazu Iinuma

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  1. Kazuya Murata
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  2. Kikuyo Nakao
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  9. Munekazu Iinuma
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  10. Hideaki Matsuda
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Corresponding author

Correspondence to Hideaki Matsuda.

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Murata, K., Nakao, K., Hirata, N. et al. Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle . J Nat Med 63, 355–359 (2009). https://doi.org/10.1007/s11418-009-0331-y

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  • DOI: https://doi.org/10.1007/s11418-009-0331-y

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