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Cell suicide for beginners

The ability to commit suicide is a fundamental property of animal cells. This overview considers recent progress in understanding the nature of the suicide process and how it is controlled.

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Figure 1: Activation of a caspase.
Figure 2: Two ways that a lymphocyte can kill a target cell.
Figure 3: How the release of cytochrome c from mitochondria contributes to apoptosis.
Figure 4: How Bcl-2 family proteins are thought to determine whether a cell lives or dies in C.elegans.
Figure 5: One way that extracellular survival factors can suppress apoptosis.

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Raff, M. Cell suicide for beginners. Nature 396, 119 (1998). https://doi.org/10.1038/24055

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