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Agreed; my point is that the FDA doesn't make that distinction. The FDA's definition of "same performance" is close, but it's not always close enough.

(I once worked on a system that had to special-case pricing for Synthroid specifically because the FDA-approved generics aren't quite the same to a lot of people, and I ended up marrying someone who gets moody when the pharmacy gives her generic Synthroid by mistake.)




Perceived reputation, color and packaging plays a big role in perceived drug efficacy[0], I wonder if a double blinded trial would show the same results you have seen anecdotally.

[0] http://www.theatlantic.com/health/archive/2014/10/the-power-...


I'd be interested to see results from such a trial.

Closer to home, we twice found out that the pharmacy gave her a generic when she developed quirks 4-5 days after she started taking a new bottle. Sort of the reverse of a placebo effect -- she thought she was on the brand all along, and she didn't think to check until things didn't feel right.

Humans are complicated.


Then isn't the FDA's claim false, if people detect different effects from brand name vs generic?




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