when i used two monitors (my expensive graphics card died T_T) i kept absolute positioning, which is one of the things i like about tablets. you don't need to know where the cursor is, you just move the pen where you want the cursor to be and it's there, so it's more direct than a mouse. it also feels more 'connective' in general. when using scrollbars for example it feels like you're "grabbing" them rather than just interacting with them. or at least it does to me

with the wacom software you can map multiple monitors to different sections of the tablet, so i mapped a large portion of the tablet to my work monitor and a smaller portion to the second. something like:

   _______________
  |               |
  |               |
  |               |  <-- monitor 1
  |               |
  |_______________|______
                  |      |  <-- monitor 2
                  |______|

actually i don't remember if i used the wacom software to map or if it was something in the desktop settings. in any case it's possible. and of course, relative positioning works fine as well

i'm sure everyone is intimately familiar with the wrist pain from mice usage. it doesn't happen with pens because your wrists aren't contorted like they are with mice. pens are more flexible since the only thing that matters is where the point is, not where the whole unit is. the hand/arm/wrist posture when using a pen is more natural than the posture you have to assume when using a mouse (notice you have to actually twist your arm thingie to use a mouse)