That "enlightened state" is, to me, an extraordinary claim, and if that exists, surely there is no reason to be defensive about it? I'm sure your studies are good, but allow me meet that person that has love, clarity, the ability to tap into some other place for creativity etc., yet at the same time has their shit together.
Have you not met monks, people who have used various drugs, or subscribe to various philosophies/religions? Many have a lot going for them but are also lacking in other areas. Hope you get what I mean.
The burden isn't to prove that there are no side-effects, just that their rate and severity are sufficiently low.