I recently got a new workstation at work that is a MacBook Pro that connects to 2 monitors via USB-C.
I've learned somewhat superstitiously that if I don't connect and disconnect the USB-C cables in the right order the laptop may stop responding and I have to do a hard reboot. I thought this solved the problem but even now it still occasionally happens.
Your question makes me wonder if something like this isn't the cause (Mac misreading USB-C signal).
Based on my experience with a pre-USB-C Macbook connected to multiple monitors, USB-C is not at all required to get them to do strange things, up to and including hard crashing, depending on the order and speed of connecting monitors and sleeping the system.
I've learned somewhat superstitiously that if I don't connect and disconnect the USB-C cables in the right order the laptop may stop responding and I have to do a hard reboot. I thought this solved the problem but even now it still occasionally happens.
Your question makes me wonder if something like this isn't the cause (Mac misreading USB-C signal).