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> Self-regulation by scientists of decades and centuries past has created modern science with all its virtues and triumphs. However, much like the bankers of the early 21st century, we risk allowing new incentives to erode our self-regulation and skew our perceptions and behavior; similar to the risky loans underlying mortgage-backed securities, faulty scientific observations can form a bubble and an unstable edifice. As science is ultimately self-correcting, faulty conclusions are remedied with ongoing study, but this takes a great deal of time.

> Unless and until leadership is taken at a structural and societal level to alter the incentive structure present, the current environment will continue to encourage and promote wasting of resources, squandering of research efforts and delaying of progress; such waste and delay is something that those suffering diseases for which we have inadequate therapy, and those suffering conditions for which we have inadequate technological remedies, can ill afford and should not be forced to endure.

I agree.




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