Not necessarily. Basically, the only deception available is overplaying or underplaying a hand. There are also other factors that determine whether it's worthwhile to bet. I'm no expert, but I think the size of the ante or current bet relative to the pot is going to make a bigger impact. A human can manipulate some of these factors to affect the way a machine plays, but this is at a great risk and various human mistakes are inevitable. The machine may be tricked into betting or folding when it shouldn't, but it can be counted on to get the arithmetic right every time. I'm not sure the risk is worth the potential reward in this situation. I'm thinking a human is going to make far more mistakes than the machine.
Deception isn't twisting your Oreo cookie one way when you've got the nuts all night, then doing it the same way later when you're bluffing. Deception is playing every hand the same way, such that your opponent can't deduce what you hold from your betting patterns. For instance, though it would clearly be a losing strategy, if someone raised at every possible opportunity, their range would always be 100% of all possible hands and you'd never have the slightest clue what they hold.
This is no less relevant against a bot than it is against a human. Odds are no more relevant against a bot than they are against a human.
The math is so trivial to calculate as to be irrelevant. And if you think humans make far more mistakes than machines, you should try downloading poki and playing a full ring game.
You can't have both. If you play optimally you lose. If you only bluff you lose. So you have to find a balance. And when you've found it, the other player will change his style so you're in the dark once again.
And the deception also affects your image (your perceived playing style). So the bets you make affect future hands, and the expected profit from future hands. That's what makes the game interesting.
What you describe is a game where you play against one of N players each hand, and you don't know which one. And every hand you get a different anonymous opponent. So basically you have no prior knowledge about your opponent, and your opponent doesn't know you. That would be a really boring game, and mostly number crunching.