Ruby - Raleigh.rb was one of the first and largest Ruby user groups, we have some of the best Ruby developers in the country. Relevance, Viget, and Terralien (gone now) are all based in the Triangle.

Clojure - Relevance employs most of the Clojure core team and the Clojure conference is held here each year.

Javascript - Good local developers and groups.

Python - no clue.