I would argue that it was industrialisation, not transport, that led to home/workplace segregation. Large mills, running on water or steam power, could not exist on a small scale or too near to residences.
Just as much, because large mills give the ability to monitor your workers. Getting people to clock on 8 hours per day (or, before the socialists changed it, 14+ hours per day) gives you much more ability to extract labour from them.
