It's 16 weeks. There are 17 regular season weeks, and we run all but the 1st.
We don't use a line, so the odds are better than that though. You can usually start off picking 10+ point favorites (which, if memory serves me, win about 85% of the time) but as you use up the better teams that worsens. For instance week 1 if you pick New England, you're a 16.5 pt favorite and will win almost always.
But yeah, the tiebreakers will handle it if it happens.