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There are thousands of species that went extinct due to engineered habitat destruction, pollution, and/or hunting.

We face an ongoing "vulture crisis" in India due to the tremendous use of antibiotics on livestock.

https://en.m.wikipedia.org/wiki/Indian_vulture_crisis

See the book "Their Fate is Our Fate" for more examples of ecological problems affecting humans, for which birds provide early warnings.

Speaking of anti-biotics, we've been so successful in our development and manufacture of these medicines that anti-biotic resistance is a significant and growing problem.

Stepping away from medicine, consider the ongoing water crisis in the Colorado River basin. We engineered our way into vast cities and agricultural projects in the desert (e.g. California's central valley) and there is now no clear path to sustaining all of these projects.




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