I've been terrified to enable jumbo frames because every guide I've read has always had "you have to make sure that every single machine you ever communicate with has to also have jumbo frames on or you will cause a black hole that sucks the whole earth into it!!" kind of disclaimers when I just want to lower the overhead in copying files from my NAS that has some pathetic Atom CPU in it.
If that's the case it's a shame we didn't take the chance with IPv6 to push to higher default MTUs since IPv6 already relies to a much higher degree on PMTUD since it lacks fragmentation.