It is difficult to grow but there are multiple producers in the US, and I've occasionally seen it for sale in grocery stores. Some sushi places use it. It is more expensive than the green horseradish/mustard powder, but not prohibitively so.
You can taste the difference but in most contexts it is pretty substitutable with the fake wasabi, hence the ubiquity of the latter.
You can taste the difference but in most contexts it is pretty substitutable with the fake wasabi, hence the ubiquity of the latter.