You'd be trading allergies for new and exciting forms of clean room/PPE-related dermatitis.

You have to isolate yourself from the CR so not to contaminate it, so I doubt that would help.

No actually it does help quite a bit. Allergies are primarily from allergens in the air and you still breathe the same air in the clean room (just through a mask). So you are going to be breathing the air minus allergens which for people with severe allergies might be worth the extra hassle of being in a cleanroom