Box64 only does 64-bit binary translations. So for example Steam cannot run on box64 alone because it's a hybrid with both 32-bit and 64-bit binaries: https://github.com/ptitSeb/box64/?tab=readme-ov-file#notes-a...

Wine has beta support for 32-bit Windows applications on 64-bit-only wine, but it's not default.

They also address it: https://docs.fedoraproject.org/en-US/fedora-asahi-remix/x86-...