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Why is it called "gain of function" if there's no gain of function?

> why lots of people are so against it

Hearing "GoF is NOT GoF" just makes me suspicious instinctively, that's all - no bad intention.




This is a nomenclature issue. But as a non-involved person, the key function of a virus is distribution/virulance. Gain of Function means increasing the effectiveness of the key function. So making a virus spread more, making an immune cell more effective against pathogens, making a retina cell more sensitive to light.

Gaining An Additional Function is not the same thing, although the confusion is understandable.


Understood, thanks for nicely explaining it instead of downvoting ;)




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