Several crystal structures of the catalytic ___domain of the protein had already been determined. The DNA binding ___domain of the protein which AlphaFold predicted is a relatively common fold that probably could have been figured out using homology modeling, which was common 10+ years ago. Even the small molecule docking used pretty old school computational techniques, and all but one drug interacted with the predetermined structures. The analysis was indeed aided by AI in the form of AlphaFold, but my guess is it sped a couple things up rather than making them possible.