I remember S-100 from when I was a kid. Never was hands-on with that hardware but there were all kinds of ads for cards in Byte magazine and others. Seemed like you could get a card for almost anything in S-100 protocol.
That's right. There are still S-100 enthusiasts who are maintaining and developing S-100 cards, see http://www.s100computers.com/ (does not seem to respond correctly to HTTPS right now).