Your logic is scattered and incoherent. You still haven't pinned down your definition of metabolic disorder, as mentioned my definition includes those caused by auto-immune. I explicitly stated that poor quality of food eaten too regularly is causative in many cases, genetics and lifestyle also plays a factor. You're hung up on the number of calories, my position is that is entirely secondary to what those calories are and the cadence of intake. There needs to be a gap in the intake for the natural GLP-1As to take effect. The point of having a mental model is to help make wise choices to optimize an outcome - your model is reductive and far too simplistic and elides many important factors that should be considered. Your position was more tenable in the absence of the data we now have. GLP1-As work, people know it works, and no amount of 'diet and exercise' is the one true path to enlightenment religiosity is going to cause people to unlearn it. I understand the strong desire to blame people for their choices, empathy is painful, and I understand the assumption that there is a price for everything - that nothing comes for free. But that presupposes a prior optimal homeostasis which for a variety of reasons we did not have. Modern diets / lifestyles created a problem that now modern medicine can help with. As a side benefit the medication works for those with my genes where diet and exercise simply wouldn't work. And in my case it's not a modern ailment, people with my genetic profile have had a rough life since before Hippocrates.