I doubt that. Sugar and HFCS are essentially the same thing, produced in different ways. Sugar (sucrose) is a 50/50 split between glucose and fructose. HFCS has more fructose in it, generally around 65/35.

There's a danger from using too much HFCS in the replacement, but really, saying sugar is healthier than HFCS is akin to saying that it's better to be punched kickboxer than a boxer.