I tried Django for one app (and never for a second one). There are so many assumptions built-in that if you build a real app and find out you need to handle a case that isn't well-supported by those assumptions, it's a painfully uphill battle. (In my experience, Django is also slow/heavy.) I know there are a lot of real apps built on Django, so maybe it's matured in the past few years, but I'd much rather use something like CherryPy or Flask that handles the common cases for me, but doesn't limit the directions my app can grow in.