Delivering a package for a random stranger has all sorts of risks. If the package contains a kilo of heroin and you get pulled over by the cops, it will be rather hard to explain to them that you knew nothing about it. That's a risk that a UPS or Fedex driver doesn't have, since they're not the ones who accepted the package.
Yea, those are issues that were considered including regulations...but I think ultimately those by them self would not be a reason not to give it a shot. If the business picks up then you can address those concerns. All the new ride sharing services face similar liability issues.
Potential criminal liability is not an issue you can pick up when you get bigger. It's an issue you have to deal with before you get started. Willful ignorance is not a defense to a charge of transporting drugs or other contraband.