Yes! Numpy is hugely popular in (at least) physics and machine learning and the main negative comment I get is "Wow that's horrible syntax". I'm still not sure they'll be convinced, however:

    trans_coef.T.dot(solve(H.dot(V).dot(H.T)), trans_coef)

becomes

    trans_coef.T @ solve(H @ V @ H.T, trans_coef)

but in MATLAB or Julia might be:

    trans_coef' * ((H * V * H') \ trans_coef)

....I want a backslash operator now!