You are including etc/cereal/include to your -I but this does not exist, and I see no probe for cereal.

    tools/orange/main.cc:12:10: fatal error:
      'cereal/types/unordered_map.hpp' file not found
    #include <cereal/types/unordered_map.hpp>

This one: https://github.com/USCiLab/cereal ? Please add it as submodule to etc.

The apple standard cc=clang-602.0.53 is not good enough. error: no matching constructor for initialization of 'llvm::EngineBuilder' EngineBuilder builder((std::unique_ptr<Module>(m_module)))

macports clang-mp-3.{3,5,6,7} even fail before with this error: no matching constructor for initialization of 'llvm::raw_fd_ostream' raw_fd_ostream raw(loutput.c_str(), ec, llvm::sys::fs::OpenFlags::F_RW)

I only have 5 clang's on my mac.