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Sites of N6-methyladenosine (m6A) in the coding region of mRNAs can induce a distinct, translation-dependent decay pathway involving mRNA translocation to P-bodies.
Obesity-induced transcriptional and epigenetic alterations persist following weight loss, which negatively affects adipose tissue function and increases the propensity to regain weight.
Zhao et al. describe how nuclear deformation during confined cell migration affects chromatin organization and biomolecular condensates. Chromatin heterogeneity in the trailing nuclear half creates a permissive environment for condensate formation, with potential roles in nuclear mechanics and chromatin interactions.
Stephen Michnick provides a brief history of protein-fragment complementation — an approach to studying protein–protein interactions in living cells — and discusses advances in its applications and possible future developments.
In this Comment article, Monika Fuxreiter discusses possible roles of dynamic, fuzzy protein interactions and their importance in changing cellular environments.
In this Tools of the Trade article, Cao (Baskin lab) discusses the development of MARS, which enables mitosis-specific recruitment of enzymes to the plasma membrane, exploiting the cell cycle’s natural regulation of PLEKHA5 phosphorylation.
Ancient proteins can provide phylogenetic information at a timescale that supersedes ancient DNA. Paleoproteomics could thus provide invaluable evolutionary insights, including into human evolution.
Tunnelling nanotubes, which are actin-based protrusions different from filopodia and cytokinetic bridges, connect cells in the zebrafish embryo, enabling the transport of proteins and organelles.
Cross-species host–pathogen or mutualistic RNA communication, especially through extracellular vesicles, can have important applications, including gene silencing in agriculture and RNA-based therapeutics.
Valerie Tornini discusses two studies that identified functional roles for small proteins encoded by short open reading frames, and highlights the potential for this research field in fundamental and clinical research.
C. David Allis’s discovery of the first histone acetyltransferase from Tetrahymena exemplifies an approach that continues to evolve and now has a crucial role in drug development.
Senescent cells in the amputated head of the cnidarian Hydractinia symbiolongicarpus drive the reprogramming of somatic cells into pluripotent stem cells, which are required for full body regeneration.
In this Tools of the Trade article, Duran (Gil lab) describes the development of novel machine learning algorithms that enable the detection of senescent cells in vitro and in diverse tissues based solely on nuclear morphologeny analysis.
James Kirkland discusses how work by Norman Sharpless and colleagues, published in 2004, paved the way for the development of senolytics, which are now in early phase clinical trials for the treatment of multiple disorders.
Ana O’Loghlen highlights a recent study that indicates that inhibiting the pro-inflammatory cytokine IL-11 has anti-ageing effects, and how such findings could have implications for the treatment of ageing-associated diseases.
Enrichment of senescent cells from organs holds great promise for studying cell senescence and ageing, and for identifying therapeutic vulnerabilities.
Akiko Takahashi discusses the seminal 1997 paper by Serrano et al. who found that oncogene activation results in a similar phenotype to replicative senescence, establishing the connection between senescence and cancer.
